Impairment of Sexual Function in Rats with Epilepsy

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dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorAlvarenga, Tathiana A. [UNIFESP]
dc.contributor.authorScorza, Fulvio A. [UNIFESP]
dc.contributor.authorMatos, Gabriela [UNIFESP]
dc.contributor.authorSonoda, Eliza Y. [UNIFESP]
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorCavalheiro, Esper A. [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:41Z
dc.date.available2016-01-24T14:27:41Z
dc.date.issued2012-09-01
dc.description.abstractIntroduction. Epilepsy is a chronic disease that affects men and women of all ages, with different levels of severity. Many individuals with epilepsy also suffer from impairments in sexual function. However, it is difficult to differentiate between the impact of the disease and the impact of antiepileptic drugs on sexual function in human subjects. Aims. To evaluate sexual behavior in adult male rats submitted to chronic pilocarpine-induced epilepsy. Methods. First, non-epileptic rats were exposed to nine training sessions to acquire sexual experience, and their baseline sexual performance was evaluated. Then, the same rats were given pilocarpine to induce status epilepticus followed by chronic epilepsy. Once the animals had developed spontaneous recurrent seizures, their sexual behavior was evaluated during three sessions. Main Outcome Measures. Examine changes in latencies to first mount, intromission, and ejaculation, and the total number of mounts, intromissions, and ejaculations. Results. All outcome measures related to sexual motivation and sexual performance were markedly impaired during chronic epilepsy compared with the baseline and the control group. Conclusion. These findings will aid in understanding the interaction between sexual behavior and epilepsy, as well as encouraging further experimental studies in human patients with epilepsy suffering from sexual dysfunction. Andersen ML, Alvarenga TA, Scorza FA, Matos G, Sonoda EY, Hirotsu C, Cavalheiro EA, and Tufik S. Impairment of sexual function in rats with epilepsy. J Sex Med 2012;9:22662272.en
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Neurol Expt, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Neurol Expt, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.description.sponsorshipIDFAPESP: 09/01030-5
dc.description.sponsorshipIDFAPESP: 11/12325-6
dc.description.sponsorshipIDFAPESP: 10/50129-1
dc.description.sponsorshipIDFAPESP: 09/14206-4
dc.format.extent2266-2272
dc.identifierhttp://dx.doi.org/10.1111/j.1743-6109.2012.02792.x
dc.identifier.citationJournal of Sexual Medicine. Hoboken: Wiley-Blackwell, v. 9, n. 9, p. 2266-2272, 2012.
dc.identifier.doi10.1111/j.1743-6109.2012.02792.x
dc.identifier.issn1743-6095
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35259
dc.identifier.wosWOS:000308391900009
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Sexual Medicine
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectSexual Behavioren
dc.subjectEpilepsyen
dc.subjectErectionen
dc.subjectSeizureen
dc.subjectPilocarpineen
dc.subjectErectile Dysfunctionen
dc.subjectAnimal Models of Impaired Sexual Functionen
dc.titleImpairment of Sexual Function in Rats with Epilepsyen
dc.typeinfo:eu-repo/semantics/article
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