Hemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participants

dc.citation.volumev. 195
dc.contributor.authorGomes, July Silveira [UNIFESP]
dc.contributor.authorDucos, Daniella Valverde [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorOrtiz, Bruno Bertolucci [UNIFESP]
dc.contributor.authorVan Deusen, Adrian Machado
dc.contributor.authorAkiba, Henrique Teruo [UNIFESP]
dc.contributor.authorGuimaraes, L. S. P.
dc.contributor.authorCordeiro, Quirino [UNIFESP]
dc.contributor.authorTrevizol, Alisson Paulino [UNIFESP]
dc.contributor.authorLacerda, Acioly Luiz Tavares de [UNIFESP]
dc.contributor.authorDias, Alvaro Machado [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractBackground: Cognitive impairments in schizophrenia are strongly correlated to functional outcome and recovery rates, with no pharmacological agent approved for its treatment. Neurofeedback has emerged as a non-pharmacological approach to enhance neuroplasticity, which consists in inducing voluntary control of brain responses through operant conditioning. Method: The effects of hemoencephalography neurofeedback (HEG-NFBK) in 4 brain sites (F7, Fp1, Fp2 and F8) was studied in 8 patients with schizophrenia (SCH, mean age 36.5 +/- 9.98) and 12 health controls (mean age 32.17 +/- 5.6). We analyzed groups' performance (10 sessions) and cognitive differences in 3 time points (baseline, after training and follow-up) with generalized estimated equations. For SCH we also evaluate the impact on psychopathology. Results: We found a group * time interaction for HEG-NFBK performance in the left hemisphere sites (F7 an Fp1) and a near-to-significant in the right frontotemporal region (F8), with no group differences and a significant time effect. Most of cognitive domains improved after intervention, including information processing speed, attention processing, working memory, executive functioning, verbal and visual learning. No group * time interaction was found. Results suggest that both groups benefit from HEG-NFBK training regardless of cognitive differences at baseline. No significant time effects were found for Calgary and PANSS total scale and subscales (positive, negative neither general). Conclusion: To our knowledge, this is the first controlled trial showing effects of NFBK on cognitive performance improvement in schizophrenia. Further research investigating the effects of HEG-NFBK training in schizophrenia should be performed. (C) 2017 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, Clin Neurosci Lab, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Ctr Neuromodulat Studies, Sao Paulo, Brazil
dc.description.affiliationItallis Consciousness Technol, Atlanta, GA USA
dc.description.affiliationUniv Fed Rio Grande do Sul, Clin Hosp Porto Alegre, Epidemiol & Biostat Unity, Porto Alegre, RS, Brazil
dc.description.affiliationSao Paulo State Secretariat Hlth, Reference Ctr Alcohol Tobacco & Other Drugs CRATOD, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Clin Neurosci Lab, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Ctr Neuromodulat Studies, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifier.citationSchizophrenia Research. Amsterdam, v. 195, p. 591-593, 2018.
dc.publisherElsevier Science Bv
dc.relation.ispartofSchizophrenia Research
dc.rightsAcesso restrito
dc.subjectNon-invasive brain stimulationen
dc.subjectHemoencephalography neurofeedbacken
dc.titleHemoencephalography self-regulation training and its impact on cognition: A study with schizophrenia and healthy participantsen