An MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humans

dc.contributor.authorSanches, Marsal [UNIFESP]
dc.contributor.authorCaetano, Sheila
dc.contributor.authorNicoletti, Mark
dc.contributor.authorMonkul, E. Serap
dc.contributor.authorChen, Hua Hsuan
dc.contributor.authorHatch, John P.
dc.contributor.authorYeh, Ping-Hong
dc.contributor.authorMullis, Rachel L.
dc.contributor.authorKeshavan, Matcheri S.
dc.contributor.authorRajowska, Grazyna
dc.contributor.authorSoares, Jair C.
dc.contributor.institutionUniv N Carolina
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Texas Hlth Sci Ctr San Antonio
dc.contributor.institutionWayne State Univ
dc.contributor.institutionUniv Mississippi
dc.description.abstractThe dorsolateral prefrontal cortex (DLPFC) has been implicated in the pathophysiology of mental disorders. Previous region-of-interest MRI studies that attempted to delineate this region adopted various landmarks and measurement techniques, with inconsistent results. We developed a new region-of-interest measurement method to obtain morphometric data of this region from structural MRI scans, taking into account knowledge from cytoarchitectonic postmortem studies and the large inter-individual variability of this region. MRI scans of 10 subjects were obtained, and DLPFC tracing was performed in the coronal plane by two independent raters using the semi-automated software Brains2. the intra-class correlation coefficients between two independent raters were 0.94 for the left DLPFC and 0.93 for the right DLPFC. the mean +/- S.D. DLPFC volumes were 9.23 +/- 2.35 ml for the left hemisphere and 8.20 +/- 2.08 ml for the right hemisphere. Our proposed method has high inter-rater reliability and is easy to implement, permitting the standardized measurement of this region for clinical research applications. (C) 2009 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv N Carolina, Ctr Excellence Res & Treatment Bipolar Disorder, Dept Psychiat, Neurosci Hosp 10612, Chapel Hill, NC 27599 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Psychiat, BR-05311970 São Paulo, Brazil
dc.description.affiliationUniv Texas Hlth Sci Ctr San Antonio, Div Mood & Anxiety Disorders, Dept Psychiat, San Antonio, TX 78229 USA
dc.description.affiliationWayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI USA
dc.description.affiliationUniv Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipVeterans Administration (VA Merit Review)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDNARSAD: MH 68766
dc.description.sponsorshipIDNARSAD: MH 69774
dc.description.sponsorshipIDNARSAD: MH61578
dc.description.sponsorshipIDNARSAD: MH60451
dc.description.sponsorshipIDNARSAD: RR17701
dc.identifier.citationPsychiatry Research-neuroimaging. Clare: Elsevier B.V., v. 173, n. 2, p. 150-154, 2009.
dc.publisherElsevier B.V.
dc.relation.ispartofPsychiatry Research-neuroimaging
dc.rightsAcesso restrito
dc.subjectBipolar disorderen
dc.titleAn MRI-based approach for the measurement of the dorsolateral prefrontal cortex in humansen