Present and Future of the Radio-Molecules used in Detection of Sentinel Lymphatic Nodes

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dc.contributor.authorFernandez Nunez, Eutimio Gustavo
dc.contributor.authorFaintuch, Bluma Linkowski
dc.contributor.authorOliveira, Relma Tavares de
dc.contributor.authorWiecek, Danielle Pereira
dc.contributor.authorTeodoro, Rodrigo
dc.contributor.authorOliveira Filho, Renato Santos de [UNIFESP]
dc.contributor.institutionInst Energet & Nucl Res
dc.contributor.institutionSalvador Allende Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T10:54:47Z
dc.date.available2018-06-18T10:54:47Z
dc.date.issued2009-03-01
dc.description.abstractDetection of the sentinel lymph node has become a mainstay of certain surgical interventions for cancer. In this sense, physiological and biochemical properties of the molecules employed for early detection of such metastasis have become relevant in many specialties. Traditionally the main characteristics considered for such radiopharmaceuticals are particle size and surface features. In addition, design of radiolabeled molecules has to take in account anatomy of the vascular lymphatic epithelium and its interaction with such agents. The aim is to create more specific and effective drugs, thus precisely shaping and eventually remodelling the surgical strategy for a given patient. Advances in diagnostic imaging open perspectives for additional categories of agents, endowed with different physico-chemical features as required by positron-emission tomography and other sophisticated procedures. This review covers the molecules used in sentinel node finding as well as some related topics, which can help to understand their action mechanism and failures.en
dc.description.affiliationInst Energet & Nucl Res, Radiopharm Ctr, BR-05508000 Sao Paulo, Brazil
dc.description.affiliationSalvador Allende Hosp, Havana, Cuba
dc.description.affiliationUniv Fed Sao Paulo, Fac Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Fac Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Commission for Nuclear Energy (CNEN, Sao Paulo, Brazil)
dc.description.sponsorshipInternational Atomic Energy Agency (IAEA, Vienna, Austria)
dc.format.extent298-303
dc.identifierhttp://www.latamjpharm.org/resumenes/28/2/LAJOP_28_2_3_1.pdf
dc.identifier.citationLatin American Journal Of Pharmacy. La Plata: Colegio Farmaceuticos Provincia De Buenos Aires, v. 28, n. 2, p. 298-303, 2009.
dc.identifier.issn0326-2383
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44843
dc.identifier.wosWOS:000269241100021
dc.language.isoeng
dc.publisherColegio Farmaceuticos Provincia De Buenos Aires
dc.relation.ispartofLatin American Journal Of Pharmacy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCanceren
dc.subjectMelanomaen
dc.subjectMetastasisen
dc.subjectRadiopharmaceuticalen
dc.subjectSentinel Lymph Nodeen
dc.titlePresent and Future of the Radio-Molecules used in Detection of Sentinel Lymphatic Nodesen
dc.typeinfo:eu-repo/semantics/article
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