Guideline for the Management of Fever and Neutropenia in Children With Cancer and/or Undergoing Hematopoietic Stem-Cell Transplantation

dc.contributor.authorLehrnbecher, Thomas
dc.contributor.authorPhillips, Robert
dc.contributor.authorAlexander, Sarah
dc.contributor.authorAlvaro, Frank
dc.contributor.authorCarlesse, Fabianne [UNIFESP]
dc.contributor.authorFisher, Brian
dc.contributor.authorHakim, Hana
dc.contributor.authorSantolaya, Maria
dc.contributor.authorCastagnola, Elio
dc.contributor.authorDavis, Bonnie L.
dc.contributor.authorDupuis, L. Lee
dc.contributor.authorGibson, Faith
dc.contributor.authorGroll, Andreas H.
dc.contributor.authorGaur, Aditya
dc.contributor.authorGupta, Ajay
dc.contributor.authorKebudi, Rejin
dc.contributor.authorPetrilli, Sergio [UNIFESP]
dc.contributor.authorSteinbach, William J.
dc.contributor.authorVillarroel, Milena
dc.contributor.authorZaoutis, Theoklis
dc.contributor.authorSung, Lillian
dc.contributor.institutionHosp Sick Children
dc.contributor.institutionGoethe Univ Frankfurt
dc.contributor.institutionUniv Childrens Hosp Muenster
dc.contributor.institutionLeeds Gen Infirm
dc.contributor.institutionUniv York
dc.contributor.institutionGreat Ormond St Hosp Sick Children
dc.contributor.institutionLondon S Bank Univ
dc.contributor.institutionJohn Hunter Childrens Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionChildrens Hosp Philadelphia
dc.contributor.institutionSt Jude Childrens Res Hosp
dc.contributor.institutionHosp Ninos Luis Calvo Mackenna
dc.contributor.institutionUniv Chile
dc.contributor.institutionIst Giannina Gaslini
dc.contributor.institutionHigh Tor
dc.contributor.institutionInst Rotary Canc Hosp
dc.contributor.institutionAll India Inst Med Sci
dc.contributor.institutionIstanbul Univ
dc.contributor.institutionDuke Univ
dc.description.abstractPurposeTo develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN).MethodsThe International Pediatric Fever and Neutropenia Guideline Panel is a multidisciplinary and multinational group composed of experts in pediatric oncology and infectious disease as well as a patient advocate. the Panel was convened for the purpose of creating this guideline. We followed previously validated procedures for creating evidence-based guidelines. Working groups focused on initial presentation, ongoing management, and empiric antifungal therapy. Each working group developed key clinical questions, conducted systematic reviews of the published literature, and compiled evidence summaries. the Grades of Recommendation Assessment, Development, and Evaluation approach was used to generate summaries, and evidence was classified as high, moderate, low, or very low based on methodologic considerations.ResultsRecommendations were made related to initial presentation (risk stratification, initial evaluation, and treatment), ongoing management (modification and cessation of empiric antibiotics), and empiric antifungal treatment (risk stratification, evaluation, and treatment) of pediatric FN. for each recommendation, the strength of the recommendation and level of evidence are presented.ConclusionThis guideline represents an evidence-based approach to FN specific to children with cancer. Although some recommendations are similar to adult-based guidelines, there are key distinctions in multiple areas. Implementation will require adaptation to the local context. J Clin Oncol 30:4427-4438. (c) 2012 by American Society of Clinical Oncologyen
dc.description.affiliationHosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada
dc.description.affiliationGoethe Univ Frankfurt, Frankfurt, Germany
dc.description.affiliationUniv Childrens Hosp Muenster, Munster, Germany
dc.description.affiliationLeeds Gen Infirm, Leeds, W Yorkshire, England
dc.description.affiliationUniv York, York YO10 5DD, N Yorkshire, England
dc.description.affiliationGreat Ormond St Hosp Sick Children, London WC1N 3JH, England
dc.description.affiliationLondon S Bank Univ, London, England
dc.description.affiliationJohn Hunter Childrens Hosp, Newcastle, NSW, Australia
dc.description.affiliationUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliationChildrens Hosp Philadelphia, Philadelphia, PA 19104 USA
dc.description.affiliationSt Jude Childrens Res Hosp, Memphis, TN 38105 USA
dc.description.affiliationHosp Ninos Luis Calvo Mackenna, Santiago, Chile
dc.description.affiliationUniv Chile, Santiago, Chile
dc.description.affiliationIst Giannina Gaslini, I-16148 Genoa, Italy
dc.description.affiliationHigh Tor, Nassau, Bahamas
dc.description.affiliationInst Rotary Canc Hosp, New Delhi, India
dc.description.affiliationAll India Inst Med Sci, New Delhi, India
dc.description.affiliationIstanbul Univ, Istanbul, Turkey
dc.description.affiliationDuke Univ, Med Ctr, Durham, NC USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipGilead Sciences
dc.description.sponsorshipAstellas Pharma
dc.description.sponsorshipIDCanadian Institutes of Health Research: 243795
dc.identifier.citationJournal of Clinical Oncology. Alexandria: Amer Soc Clinical Oncology, v. 30, n. 35, p. 4427-4438, 2012.
dc.publisherAmer Soc Clinical Oncology
dc.relation.ispartofJournal of Clinical Oncology
dc.rightsAcesso restrito
dc.titleGuideline for the Management of Fever and Neutropenia in Children With Cancer and/or Undergoing Hematopoietic Stem-Cell Transplantationen