Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

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dc.citation.issue4
dc.citation.volume19
dc.contributor.authorAbreu, Alin
dc.contributor.authorPinzon Tovar, Alejandro
dc.contributor.authorCastellanos, Rafael
dc.contributor.authorValenzuela, Alex
dc.contributor.authorGomez Giraldo, Claudia Milena
dc.contributor.authorCastellanos Pinedo, Alejandro
dc.contributor.authorPantoja Guerrero, Doly
dc.contributor.authorBuiles Barrera, Carlos Alfonso
dc.contributor.authorIgnacio Franco, Humberto
dc.contributor.authorRibeiro-Oliveira, Antonio, Jr.
dc.contributor.authorVilar, Lucio
dc.contributor.authorJallad, Raquel S.
dc.contributor.authorDuarte, Felipe Gaia
dc.contributor.authorGadelha, Monica
dc.contributor.authorBoguszewski, Cesar Luiz
dc.contributor.authorAbucham, Julio [UNIFESP]
dc.contributor.authorNaves, Luciana A.
dc.contributor.authorMusolino, Nina Rosa C.
dc.contributor.authorJustamante de Faria, Maria Estela
dc.contributor.authorRossato, Ciliana
dc.contributor.authorBronstein, Marcello D.
dc.coverageNew York
dc.date.accessioned2020-08-14T13:44:05Z
dc.date.available2020-08-14T13:44:05Z
dc.date.issued2016
dc.description.abstractAcromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life. We conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment. Successful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management.en
dc.description.affiliationCtr Med Imbanaco Cali, Endocrinol Unit, Cali, Colombia
dc.description.affiliationUniv Surcolombiana, Hosp Neiva, Dept Internal Med, Neiva, Colombia
dc.description.affiliationUniv Ind Santander, Dept Internal Med, Bucaramanga, Colombia
dc.description.affiliationUniv Rosario, Inst Cardiol, Dept Internal Med, Endocrinol Fdn Cardioinfantil, Bogota, Colombia
dc.description.affiliationHosp Univ San Ignacio, Endocrinol Unit, Bogota, Colombia
dc.description.affiliationHosp San Jeronimo Monteria, Dept Internal Med, Monteria, Cordoba, Colombia
dc.description.affiliationUniv Nacl Colombia, Hosp Univ Dept Narino, Endocrinol Unit, CTR Endocrinol CENDOO, Pasto, Colombia
dc.description.affiliationUniv Antioquia, Hosp Univ San Vicente Fdn, Dept Endocrinol, Medellin, Colombia
dc.description.affiliationUniv Caldas, Endocrinol Fac, Manizales, Colombia
dc.description.affiliationUniv Fed Minas Gerais, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Fed Pernambuco, Sch Med, Hosp Clin, Endocrinol & Chair,Div Endocrinol, Recife, PE, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Hosp Clin, Neuroendocrine Unit,Div Endocrinol & Metab, Ave Dr Eneas de Carvalho 255,7 Andar,Sala 7037, BR-05403000 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Sch Med, Endocrine Sect, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil
dc.description.affiliationUniv Fed Parana, Dept Internal Med, Endocrine Div SEMPR, Curitiba, Parana, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Neuroendocrine Unit, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Brasilia, Fac Med, Dept Endocrinol, Brasilia, DF, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Hosp Clin, Neuroendocrine Unit,Div Neurosurg, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med, Hosp Clin, Dept Odontol,Cent Unit, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Neuroendocrine Unit, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipIpsen
dc.format.extent448-457
dc.identifierhttp://dx.doi.org/10.1007/s11102-016-0725-2
dc.identifier.citationPituitary. New York, v. 19, n. 4, p. 448-457, 2016.
dc.identifier.doi10.1007/s11102-016-0725-2
dc.identifier.issn1386-341X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57508
dc.identifier.wosWOS:000379350000014
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofPituitary
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAcromegaly diagnosisen
dc.subjectAcromegaly comorbiditiesen
dc.subjectLatin Americaen
dc.titleChallenges in the diagnosis and management of acromegaly: a focus on comorbiditiesen
dc.typeinfo:eu-repo/semantics/article
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