Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder

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Data
2011-04-01
Autores
Masruha, Marcelo Rodrigues [UNIFESP]
Lin, Jaime [UNIFESP]
Arita, Juliana Harumi [UNIFESP]
Castro Neto, Eduardo Ferreira de [UNIFESP]
Scerni, Debora Amado [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
Naffah Mazzacoratti, Maria da Graca [UNIFESP]
Vilanova, Luiz Celso Pereira [UNIFESP]
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Spontaneous periodic episodes of hypothermia still defy medical knowledge. in 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebro-spinal fluid.
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Developmental Medicine and Child Neurology. Malden: Wiley-Blackwell, v. 53, n. 4, p. 378-380, 2011.