Spontaneous periodic hypothermia and hyperhidrosis: a possibly novel cerebral neurotransmitter disorder
Data
2011-04-01
Autores
Masruha, Marcelo Rodrigues 
Lin, Jaime
Arita, Juliana Harumi
Castro Neto, Eduardo Ferreira de
Scerni, Debora Amado
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Spontaneous periodic episodes of hypothermia still defy medical knowledge. in 1969, Shapiro et al. described the first two cases of spontaneous periodic hypothermia associated with agenesis of the corpus callosum. Recently, Dundar et al. reported a case of spontaneous periodic hypothermia and hyperhidrosis without corpus callosum agenesis, suggesting that the periodic episodes of hypothermia might be of epileptiform origin. Here we describe two paediatric patients with spontaneous periodic hypothermia without corpus callosum agenesis and demonstrate, to our knowledge for the first time, altered levels of neurotransmitter metabolites within the cerebro-spinal fluid.
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Developmental Medicine and Child Neurology. Malden: Wiley-Blackwell, v. 53, n. 4, p. 378-380, 2011.