Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats

dc.contributor.authorMedeiros, Alessandra [UNIFESP]
dc.contributor.authorOliveira, Edilamar Menezes de
dc.contributor.authorGianolla, R.
dc.contributor.authorCasarini, Dulce Elena [UNIFESP]
dc.contributor.authorNegrão, C.e.
dc.contributor.authorBrum, Patricia Chakur
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:22Z
dc.date.available2015-06-14T13:31:22Z
dc.date.issued2004-12-01
dc.description.abstractThe effect of swimming training (ST) on vagal and sympathetic cardiac effects was investigated in sedentary (S, N = 12) and trained (T, N = 12) male Wistar rats (200-220 g). ST consisted of 60-min swimming sessions 5 days/week for 8 weeks, with a 5% body weight load attached to the tail. The effect of the autonomic nervous system in generating training-induced resting bradycardia (RB) was examined indirectly after cardiac muscarinic and adrenergic receptor blockade. Cardiac hypertrophy was evaluated by cardiac weight and myocyte morphometry. Plasma catecholamine concentrations and citrate synthase activity in soleus muscle were also determined in both groups. Resting heart rate was significantly reduced in T rats (355 ± 16 vs 330 ± 20 bpm). RB was associated with a significantly increased cardiac vagal effect in T rats (103 ± 25 vs 158 ± 40 bpm), since the sympathetic cardiac effect and intrinsic heart rate were similar for the two groups. Likewise, no significant difference was observed for plasma catecholamine concentrations between S and T rats. In T rats, left ventricle weight (13%) and myocyte dimension (21%) were significantly increased, suggesting cardiac hypertrophy. Skeletal muscle citrate synthase activity was significantly increased by 52% in T rats, indicating endurance conditioning. These data suggest that RB induced by ST is mainly mediated parasympathetically and differs from other training modes, like running, that seems to mainly decrease intrinsic heart rate in rats. The increased cardiac vagal activity associated with ST is of clinical relevance, since both are related to increased life expectancy and prevention of cardiac events.en
dc.description.affiliationUniversidade de São Paulo Escola de Educação Física e Esporte Departamento de Biodinâmica do Movimento do Corpo Humano
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Instituto do Coração
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital do Rim e Hipertensão
dc.description.affiliationUnifespUNIFESP, EPM, Hospital do Rim e Hipertensão
dc.description.sourceSciELO
dc.format.extent1909-1917
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2004001200018
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 12, p. 1909-1917, 2004.
dc.identifier.doi10.1590/S0100-879X2004001200018
dc.identifier.fileS0100-879X2004001200018.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2004001200018
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2322
dc.identifier.wosWOS:000225509100018
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectSwimming-training exerciseen
dc.subjectCardiac autonomic balanceen
dc.subjectHemodynamicsen
dc.subjectHypertrophic effecten
dc.subjectParasympathetic systemen
dc.subjectResting bradycardiaen
dc.titleSwimming training increases cardiac vagal activity and induces cardiac hypertrophy in ratsen
dc.typeArtigo
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