An enteroaggregative Escherichia coli strain of serotype O111 : H12 damages and invades cultured T84 cells and human colonic mucosa

dc.contributor.authorAbe, Cecilia Mari [UNIFESP]
dc.contributor.authorKnutton, Stuart
dc.contributor.authorPedroso, Margareth Z. [UNIFESP]
dc.contributor.authorFreymuller, Edna [UNIFESP]
dc.contributor.authorGomes, Tania Aparecida Tardelli [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Birmingham
dc.date.accessioned2016-01-24T12:31:29Z
dc.date.available2016-01-24T12:31:29Z
dc.date.issued2001-09-25
dc.description.abstractThe pathogenic mechanisms of enteroaggregative Escherichia coh (EAEC) are not well defined. We investigated the interaction of EAEC strain 236 (serotype O111:H12) with polarised Caco-2 and T84 human intestinal epithelia] cells lines, and,vith human jejunal and colonic mucosa. Strain 236 adhered to both polarised cell lines and to both intestinal tissue types, but caused severe damage and was invasive only in T84 cells and colonic mucosa. in contrast, prototype EAEC strain 042, which also adhered to the Cultured intestinal cell lines, did not adhere to or invade jejunal or colonic tissue. These observations suggest a heterogeneity of virulence properties within the EAEC category of diarrhoea-causing E. coli. (C) 2001 Federation of European Microbiological Societies. Published by Elsevier Science BN. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Birmingham, Inst Child Hlth, Birmingham B4 6NH, W Midlands, England
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Microscopia Eletron, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Microbiol Immunol & Parasitol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Ctr Microscopia Eletron, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent199-205
dc.identifierhttp://dx.doi.org/10.1111/j.1574-6968.2001.tb10841.x
dc.identifier.citationFems Microbiology Letters. Amsterdam: Elsevier B.V., v. 203, n. 2, p. 199-205, 2001.
dc.identifier.doi10.1111/j.1574-6968.2001.tb10841.x
dc.identifier.issn0378-1097
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26628
dc.identifier.wosWOS:000171422500011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFems Microbiology Letters
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectenteroaggregativeen
dc.subjectEscherichia colien
dc.subjectinvasionen
dc.subjectvirulence propertiesen
dc.subjectadherenceen
dc.titleAn enteroaggregative Escherichia coli strain of serotype O111 : H12 damages and invades cultured T84 cells and human colonic mucosaen
dc.typeArtigo
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