Stress, immunity and skin collagen integrity: Evidence from animal models and clinical conditions

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dc.contributor.authorKahan, V. [UNIFESP]
dc.contributor.authorAndersen, M. L. [UNIFESP]
dc.contributor.authorTomimori, J. [UNIFESP]
dc.contributor.authorTufik, S. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:53Z
dc.date.available2016-01-24T13:58:53Z
dc.date.issued2009-11-01
dc.description.abstractThe skin is the largest organ of the human body and plays a major role in maintaining homeostasis and protection. As the main component of skin, collagen has a key role in providing integrity and elasticity to this organ. Several factors, including autoimmune disease, aging, and stress, can change the quantity and integrity of skin collagen. These factors impair collagen quality and consequently affect skin function. Stress seems to affect the integrity of skin collagen through glucocorticoid-mediated processes that alter its synthesis and degradation. Glucocorticoids also affect skin quality through modulation of the immune system. This review will briefly present comprehensive data from both animal and human studies delineating processes that modulate alterations in collagen in general, and will treat in more detail the consequences of stress on skin collagen. (C) 2009 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Dermatol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.format.extent1089-1095
dc.identifierhttp://dx.doi.org/10.1016/j.bbi.2009.06.002
dc.identifier.citationBrain Behavior and Immunity. San Diego: Academic Press Inc Elsevier Science, v. 23, n. 8, p. 1089-1095, 2009.
dc.identifier.doi10.1016/j.bbi.2009.06.002
dc.identifier.issn0889-1591
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31922
dc.identifier.wosWOS:000271754700008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Behavior and Immunity
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSkin integrityen
dc.subjectCollagenen
dc.subjectStressen
dc.subjectImmune systemen
dc.subjectGlucocorticoidsen
dc.subjectAgingen
dc.subjectSleep deprivationen
dc.titleStress, immunity and skin collagen integrity: Evidence from animal models and clinical conditionsen
dc.typeinfo:eu-repo/semantics/article
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