Peptides of the Constant Region of Antibodies Display Fungicidal Activity

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Data
2012-03-21
Autores
Polonelli, Luciano
Ciociola, Tecla
Magliani, Walter
Zanello, Pier Paolo
D'Adda, Tiziana
Galati, Serena
De Bernardis, Flavia
Arancia, Silvia
Gabrielli, Elena
Pericolini, Eva
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Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.
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Plos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012.