Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats

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dc.contributor.authorChagas, Marcos Hortes N.
dc.contributor.authorCrippa, Jose Alexandre S.
dc.contributor.authorZuardi, Antonio Waldo
dc.contributor.authorHallak, Jaime E. C.
dc.contributor.authorMachado-de-Sousa, Joao Paulo
dc.contributor.authorHirotsu, Camila [UNIFESP]
dc.contributor.authorMaia, Lucas [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:31:22Z
dc.date.available2016-01-24T14:31:22Z
dc.date.issued2013-03-01
dc.description.abstractCannabidiol (CBD) is one of the main components of Cannabis sativa and has a wide spectrum of action, including effects in the sleep-wake cycle.Objective: the objective of this paper is to assess the effects on sleep of acute systemic administration of CBD.Method: Adult male Wistar rats were randomly distributed into four groups that received intraperitoneal injections of CBD 2.5 mg/kg, CBD 10 mg/kg, CBD 40 mg/kg or vehicle (n=seven animals/group). Sleep recordings were made during light and dark periods for four days: two days of baseline recording, one day of drug administration (test), and one day after drug (post-test).Results: During the light period of the test day, the total percentage of sleep significantly increased in the groups treated with 10 and 40 mg/kg of CBD compared to placebo. REM sleep latency increased in the group injected with CBD 40 mg/kg and was significantly decreased with the dose of 10 mg/kg on the post-test day. There was an increase in the time of SWS in the group treated with CBD 40 mg/kg, although this result did not reach statistical significance.Conclusion: the systemic acute administration of CBD appears to increase total sleep time, in addition to increasing sleep latency in the light period of the day of administration.en
dc.description.affiliationUniv São Paulo, Dept Neurosci & Behav, Ribeirao Preto Med Sch, INCT Translat Med CNPq, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Psychobiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent312-316
dc.identifierhttp://dx.doi.org/10.1177/0269881112474524
dc.identifier.citationJournal of Psychopharmacology. London: Sage Publications Ltd, v. 27, n. 3, p. 312-316, 2013.
dc.identifier.doi10.1177/0269881112474524
dc.identifier.issn0269-8811
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36067
dc.identifier.wosWOS:000316907400009
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectCannabidiolen
dc.subjectsleepen
dc.subjectsleep-wake cycleen
dc.titleEffects of acute systemic administration of cannabidiol on sleep-wake cycle in ratsen
dc.typeinfo:eu-repo/semantics/article
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