DECREASED SUSCEPTIBILITY TO SEIZURES INDUCED BY BICUCULLINE AFTER TRANSIENT BILATERAL CLAMPING of the CAROTID ARTERIES in RATS

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dc.contributor.authorSieklucka, M.
dc.contributor.authorBortolotto, Z.
dc.contributor.authorHeim, C.
dc.contributor.authorBlock, F.
dc.contributor.authorSontag, K. H.
dc.contributor.institutionUNIV GOTTINGEN
dc.contributor.institutionMAX PLANCK INST EXPTL MED
dc.contributor.institutionINST CLIN PATHOL
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T11:40:01Z
dc.date.available2016-01-24T11:40:01Z
dc.date.issued1991-01-01
dc.description.abstractRats were exposed for 24 min to bilateral clamping of the common carotid arteries (BCCA) in pentobarbital anaesthesia. 14 days later the animals were subjected to subcutaneous injection of (+)-bicuculline (3 or 4 mg/kg). A significantly decreased susceptibility to bicuculline-induced seizures could be observed in BCCA treated rats compared with sham operated controls. It is suggested that BCCA treatment protects animals against status epilepticus and lethal toxicity produced by bicuculline. Electrographic recordings of the BCCA animals revealed no ictal activity within 1 h after bicuculline injection. An analysis of the GABA content showed a significant increase in the hippocampus (HPC), frontal cortex (FCX), parietal cortex and substantia nigra in BCCA animals compared with controls. It is therefore possible that an increase in GABA content postsynaptically counteracts the GABA(A) antagonistic effect of bicuculline in BCCA animals thus preventing the normal seizure inducing effect of this substance.en
dc.description.affiliationUNIV GOTTINGEN,DEPT PSYCHIAT,VON SIEBOLD STR 5,W-3400 GOTTINGEN,GERMANY
dc.description.affiliationMAX PLANCK INST EXPTL MED,DEPT PHARMACOL,W-3400 GOTTINGEN,GERMANY
dc.description.affiliationINST CLIN PATHOL,DEPT PHARMACOL,LUBLIN,POLAND
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT EXPTL NEUROL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT EXPTL NEUROL,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent127-137
dc.identifierhttp://dx.doi.org/10.1007/BF01244459
dc.identifier.citationJournal of Neural Transmission-general Section. Vienna: Springer-verlag Wien, v. 83, n. 1-2, p. 127-137, 1991.
dc.identifier.doi10.1007/BF01244459
dc.identifier.issn0300-9564
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25180
dc.identifier.wosWOS:A1991ER30900013
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal of Neural Transmission-general Section
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectSEIZUREen
dc.subjectSTATUS EPILEPTICUSen
dc.subjectBICUCULLINEen
dc.subjectGABAen
dc.subjectCEREBRAL PROTECTIONen
dc.subjectCAROTID OCCLUSIONen
dc.titleDECREASED SUSCEPTIBILITY TO SEIZURES INDUCED BY BICUCULLINE AFTER TRANSIENT BILATERAL CLAMPING of the CAROTID ARTERIES in RATSen
dc.typeinfo:eu-repo/semantics/article
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