Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression

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dc.contributor.authorSilva, Sergio Gomes da [UNIFESP]
dc.contributor.authorDoná, Flávia [UNIFESP]
dc.contributor.authorSilva Fernandes, Maria Jose da [UNIFESP]
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:59:16Z
dc.date.available2016-01-24T13:59:16Z
dc.date.issued2010-02-01
dc.description.abstractIn order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining Study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill between postnatal day 21 and 60. Running time and speed were gradually increased during the subsequent days until 18 m/min for 60 min. After the aerobic exercise program, animals of all groups were killed and PV immunostaining procedures were performed. the results showed significant increase of protein level in the hippocampal formation and PV-immunoreactive neurons in CA1 and CA2/CA3 regions of rats submitted to exercise when compared with control rats. This finding indicates that aerobic exercise program during adolescent period promotes neuroplastic changes in hippocampal formation. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipClnAPCe
dc.format.extent137-142
dc.identifierhttp://dx.doi.org/10.1016/j.braindev.2008.12.012
dc.identifier.citationBrain & Development. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 137-142, 2010.
dc.identifier.doi10.1016/j.braindev.2008.12.012
dc.identifier.issn0387-7604
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32219
dc.identifier.wosWOS:000274710000010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain & Development
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPhysical exerciseen
dc.subjectRunningen
dc.subjectAdolescenceen
dc.subjectHippocampal formationen
dc.subjectParvalbuminen
dc.subjectPlasticityen
dc.titlePhysical exercise during the adolescent period of life increases hippocampal parvalbumin expressionen
dc.typeinfo:eu-repo/semantics/article
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