CHOROIDAL THICKNESS in PATIENTS WITH DIABETIC RETINOPATHY ANALYZED BY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY

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dc.contributor.authorRegatieri, Caio V. [UNIFESP]
dc.contributor.authorBranchini, Lauren
dc.contributor.authorCarmody, Jill
dc.contributor.authorFujimoto, James G.
dc.contributor.authorDuker, Jay S.
dc.contributor.institutionTufts Med Ctr
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBoston Univ
dc.contributor.institutionMIT
dc.date.accessioned2016-01-24T14:26:57Z
dc.date.available2016-01-24T14:26:57Z
dc.date.issued2012-03-01
dc.description.abstractPurpose: This study was designed to examine choroidal thickness in patients with diabetes using spectral-domain optical coherence tomography.Methods: Forty-nine patients (49 eyes) with diabetes and 24 age-matched normal subjects underwent high-definition raster scanning using spectral-domain optical coherence tomography with frame enhancement software. Patients with diabetes were classified into 3 groups: 11 patients with mild or moderate nonproliferative diabetic retinopathy and no macular edema, 18 patients with nonproliferative diabetic retinopathy and diabetic macular edema, and 20 patients with treated proliferative diabetic retinopathy and no diabetic macular edema (treated proliferative diabetic retinopathy). Choroidal thickness was measured from the posterior edge of the retinal pigment epithelium to the choroid/sclera junction at 500-mu m intervals up to 2,500 mu m temporal and nasal to the fovea.Results: Reliable measurements of choroidal thickness were obtainable in 75.3% of eyes examined. Mean choroidal thickness showed a pattern of thinnest choroid nasally, thickening in the subfoveal region, and thinning again temporally in normal subjects and patients with diabetes. Mean subfoveal choroidal thickness was thinner in patients with diabetic macular edema (63.3 mu m, 27.2%, P < 0.05) or treated proliferative diabetic retinopathy (69.6 mu m, 30.0%, P < 0.01), compared with normal subjects. There was no difference between nonproliferative diabetic retinopathy and normal subjects.Conclusion: Choroidal thickness is altered in diabetes and may be related to the severity of retinopathy. Presence of diabetic macular edema is associated with a significant decrease in the choroidal thickness. RETINA 32: 563-568, 2012en
dc.description.affiliationTufts Med Ctr, New England Eye Ctr, Boston, MA 02111 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationBoston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
dc.description.affiliationMIT, Dept Elect Engn & Comp Sci, Elect Res Lab, Cambridge, MA 02139 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipResearch to Prevent Blindness
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipAir Force Office of Scientific Research
dc.description.sponsorshipCarl Zeiss Meditech, Inc
dc.description.sponsorshipOptovue, Inc
dc.description.sponsorshipTopcon Medical Systems, Inc.
dc.description.sponsorshipIDNational Institutes of Health: RO1-EY11289-23
dc.description.sponsorshipIDNational Institutes of Health: R01-EY13178-07
dc.description.sponsorshipIDNational Institutes of Health: R01-EY013516-07
dc.description.sponsorshipIDAir Force Office of Scientific Research: FA9550-07-1-0101
dc.description.sponsorshipIDAir Force Office of Scientific Research: FA9550-07-1-0014
dc.format.extent563-568
dc.identifierhttp://dx.doi.org/10.1097/IAE.0B013E31822F5678
dc.identifier.citationRetina-the Journal of Retinal and Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 32, n. 3, p. 563-568, 2012.
dc.identifier.doi10.1097/IAE.0B013E31822F5678
dc.identifier.issn0275-004X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34691
dc.identifier.wosWOS:000300907200020
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofRetina-the Journal of Retinal and Vitreous Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectchoroiden
dc.subjectchoroidal angiopathyen
dc.subjectdiabetes mellitusen
dc.subjectdiabetic retinopathyen
dc.subjectoptical coherence tomographyen
dc.titleCHOROIDAL THICKNESS in PATIENTS WITH DIABETIC RETINOPATHY ANALYZED BY SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHYen
dc.typeinfo:eu-repo/semantics/article
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