Cholinergic modulation of inhibitory avoidance impairment induced by paradoxical sleep deprivation

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dc.contributor.authorBueno, OFA
dc.contributor.authorOliveira, MGM
dc.contributor.authorLobo, L. L.
dc.contributor.authorMorais, P. R.
dc.contributor.authorMelo, FHM
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:31:05Z
dc.date.available2016-01-24T12:31:05Z
dc.date.issued2000-05-01
dc.description.abstract1. Male Wister rats were submitted to paradoxical sleep deprivation for 96 hr by a modified multiple platform technique.2. Training of step-through inhibitory avoidance was performed immediately after the last day of paradoxical sleep deprivation. Twenty-four hr after training the animals were submitted to the retention test.3. in Experiment 1, pilocarpine (4 mg/kg, i.p.) or atropine (4 mg/kg, i.p.) were administered daily during. the paradoxical sleep deprivation period. Pilocarpine, but not atropine, reversed the impairment induced by PS deprivation.4. in Experiment 2, pilocarpine (4, 8 and 12 mg/kg, i.p.) was injected 1 hr before training in order to verify if the reversal of memory impairment was an effect secondary to residual enhanced blood levels of pilocarpine during training. Acute treatment with pilocarpine, in any dose, did not reverse the impairment produced by paradoxical sleep deprivation5. Activation of the cholinergic system during the period ol:deprivation is able to prevent memory deficits induced by paradoxical sleep deprivation.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, UNIFESP, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent595-606
dc.identifierhttp://dx.doi.org/10.1016/S0278-5846(00)00095-6
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 24, n. 4, p. 595-606, 2000.
dc.identifier.doi10.1016/S0278-5846(00)00095-6
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26304
dc.identifier.wosWOS:000087717900008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectatropineen
dc.subjectcholinergic systemen
dc.subjectinhibitory avoidance learningen
dc.subjectmemoryen
dc.subjectparadoxical sleep deprivationen
dc.subjectpilocarpineen
dc.titleCholinergic modulation of inhibitory avoidance impairment induced by paradoxical sleep deprivationen
dc.typeinfo:eu-repo/semantics/article
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