Over-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosa

dc.contributor.authorMartins, Fernanda Prata [UNIFESP]
dc.contributor.authorArtigiani Neto, Ricardo [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorCosta, Patricia Piauilino da [UNIFESP]
dc.contributor.authorForones, Nora Manoukian [UNIFESP]
dc.contributor.authorFerrari, Angelo Paulo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:37:11Z
dc.date.available2015-06-14T13:37:11Z
dc.date.issued2007-11-01
dc.description.abstractEctopic gastric mucosa (EGM) is considered to be a congenital condition. Rare cases of adenocarcinoma have been described. There are no data justifying regular biopsies or follow-up. Cyclooxygenase-2 (COX-2) is a protein involved in gastrointestinal tumor development by inhibiting apoptosis and regulating angiogenesis. The aim of this prospective study was to evaluate COX-2 expression in EGM and compare it with normal tissue and Barrett's esophagus. We evaluated 1327 patients. Biopsies were taken from the inlet patch for histological evaluation and from the gastric antrum to assess Helicobacter pylori infection. Biopsies taken from normal esophageal, gastric antrum and body mucosa and Barrett's esophagus were retrieved from a tissue bank. EGM biopsies were evaluated with respect to type of epithelium, presence of H. pylori, and inflammation. COX-2 was detected by immunohistochemistry using the avidin-biotin complex. EGM islets were found in 14 patients (1.1%). Histological examination revealed fundic type epithelium in 58.3% of cases, H. pylori was present in 50% and chronic inflammation in 66.7%. Expression of COX-2 was negative in normal distal esophagus, normal gastric antrum and normal gastric body specimens (10 each). In contrast, EGM presented over-expression of COX-2 in 41.7% of cases and Barrett's esophagus in 90% of cases (P = 0.04 and 0.03, respectively). COX-2 immunoexpression in EGM was not related to gender, age, epithelium type, presence of inflammation or intestinal metaplasia, H. pylori infection, or any endoscopic finding. Our results demonstrate up-regulation of COX-2 in EGM, suggesting a possible malignant potential of this so-called harmless mucosa.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Gastroenterologia
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Patologia
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Gastroenterologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Patologia
dc.description.sourceSciELO
dc.format.extent1447-1454
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2007001100005
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 11, p. 1447-1454, 2007.
dc.identifier.doi10.1590/S0100-879X2007001100005
dc.identifier.fileS0100-879X2007001100005.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2007001100005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/3990
dc.identifier.wosWOS:000250175400005
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso aberto
dc.subjectEndoscopyen
dc.subjectEctopic gastric mucosaen
dc.subjectCyclooxygenase-2en
dc.subjectBarrett's esophagusen
dc.subjectGastric biopsiesen
dc.titleOver-expression of cyclooxygenase-2 in endoscopic biopsies of ectopic gastric mucosaen
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