Chondroitin sulfate and glucosamine sulfate associated to photobiomodulation prevents degenerative morphological changes in an experimental model of osteoarthritis in rats

dc.citation.issue3
dc.citation.volumev. 33
dc.contributor.authorSanches, Marcella [UNIFESP]
dc.contributor.authorAssis, Livia [UNIFESP]
dc.contributor.authorCriniti, Cyntia [UNIFESP]
dc.contributor.authorFernandes, Danilo [UNIFESP]
dc.contributor.authorTim, Carla [UNIFESP]
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-20T16:31:11Z
dc.date.available2020-07-20T16:31:11Z
dc.date.issued2018
dc.description.abstractThe aim of this study was to compare the effects of combined treatment with chondroitin sulfate and glucosamine sulfate (CS/Gl) and photobiomodulation (PBM) on the degenerative process related to osteoarthritis (OA) in the articular cartilage in rats. Forty male Wistar rats were randomly divided into four groups: OA control group (CG)en
dc.description.abstractOA animals submitted to PBM treatment (PBM)en
dc.description.abstractOA animals submitted to CS/Gl treatment (CS/Gl)en
dc.description.abstractOA submitted to CS/GS associated with PBM treatments (GS/Gl + PBM). The CS/Gl started 48 h after the surgery, and they were performed for 29 consecutive days. Moreover, PBM was performed after the CS/Gl administration on the left joint. Morphological characteristics and immunoexpression of interleukin 10 (IL-10) and 1 beta (IL-1 beta) and collagen type II (Col II) of the articular cartilage were evaluated. The results showed that all treated groups (CS/Gl and PBM) presented attenuation signs of degenerative process (measured by histopathological analysis) and lower density chondrocytes [PBM (p = 0.0017)en
dc.description.abstractCS/Gl (p = 0.0153) and CS/Gl + PBM (p = 0.002)]. Additionally, CS/Gl [associated (p = 0.0089) or not with PBM (p = 0.0059)] showed significative lower values for OARSI grade evaluation. Furthermore, CS/GS + PBM decreased IL-1 beta protein expression (p = 0.0359) and increased IL-10 (p = 0.028) and Col II imunoexpression (p = 0.0204) compared to CG. This study showed that CS/Gl associated with PBM was effective in modulating inflammatory process and preventing the articular tissue degradation in the knees OA rats.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biosci, R Silva Jardim 136, BR-11015020 Santos, SP, Brazil
dc.description.affiliationBrazil Univ, Dept Biomed Engn, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biosci, R Silva Jardim 136, BR-11015020 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent549-557
dc.identifierhttp://dx.doi.org/10.1007/s10103-017-2401-9
dc.identifier.citationLasers In Medical Science. London, v. 33, n. 3, p. 549-557, 2018.
dc.identifier.doi10.1007/s10103-017-2401-9
dc.identifier.issn0268-8921
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55765
dc.identifier.wosWOS:000428056300012
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers In Medical Science
dc.rightsAcesso restrito
dc.subjectChondroitin sulfateen
dc.subjectGlucosamine sulfateen
dc.subjectPhotobiomodulationen
dc.subjectArticular cartilageen
dc.subjectKnee osteoarthritisen
dc.titleChondroitin sulfate and glucosamine sulfate associated to photobiomodulation prevents degenerative morphological changes in an experimental model of osteoarthritis in ratsen
dc.typeArtigo
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