Early Changes in Postprandial Gallbladder Emptying in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass: Correlation with the Occurrence of Biliary Sludge and Gallstones

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dc.contributor.authorBastouly, Michel [UNIFESP]
dc.contributor.authorArasaki, Carlos Haruo [UNIFESP]
dc.contributor.authorFerreira, Jael Brasil
dc.contributor.authorZanoto, Arnaldo
dc.contributor.authorBorges, Fabiola Gouveia H. P.
dc.contributor.authorDel Grande, José Carlos [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Santa Casa Santos
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T13:52:03Z
dc.date.available2016-01-24T13:52:03Z
dc.date.issued2009-01-01
dc.description.abstractGallstones have been frequently diagnosed after Roux-en-Y gastric bypass (RYGBP). Gallbladder stasis associated with duodenal exclusion may play a role in their pathogenesis.Gallbladder emptying was studied before and on the 30th and 31st postoperative days (POD) after RYGBP in 20 morbidly obese patients. Gallbladder volume after fasting and every 15 min during a 2-h period following administration of a standard liquid meal was determined by sonography. On the 31st POD, the meal was administered through the gastrostomy in order to promote its transit through the duodenum. Fasting volume (FV), maximum ejection fraction (Max EF), and residual volume (RV) were determined. Biliary sludge and calculi were investigated after 1 and 6 months, respectively.FV was 39.4 +/- 20.2 ml, 50.1 +/- 22.7 ml, and 47.9 +/- 23.4 ml, respectively, for the preoperative and two postoperative assessments (P = 0.09). RV was 7.6 +/- 8.7 ml, 25.1 +/- 20.0 ml, and 24.6 +/- 20.9 ml; and Max EF was 80.5 +/- 20.9%, 54.3 +/- 21.4%, and 50.5 +/- 29.0%, respectively, for the pre-, postoral, and postgastrostomy infusion measurements. There was only a significant difference between the preoperative value and the two postoperative values (P < 0.001). Biliary sludge was detected in 65% of the patients and 46% of them subsequently developed gallstones.Gallbladder emptying became significantly compromised after RYGBP. This impairment was unrelated to duodenal exclusion but it was associated with biliary sludge and stone formation.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationHosp Santa Casa Santos, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Esophagus Stomach & Small Bowel, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Esophagus Stomach & Small Bowel, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent22-28
dc.identifierhttp://dx.doi.org/10.1007/s11695-008-9648-y
dc.identifier.citationObesity Surgery. New York: Springer, v. 19, n. 1, p. 22-28, 2009.
dc.identifier.doi10.1007/s11695-008-9648-y
dc.identifier.issn0960-8923
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31158
dc.identifier.wosWOS:000262281700005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofObesity Surgery
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectMorbid obesityen
dc.subjectCholelithiasisen
dc.subjectGallbladder emptyingen
dc.subjectGastroplastyen
dc.subjectUltrasonographyen
dc.subjectBariatric surgeryen
dc.titleEarly Changes in Postprandial Gallbladder Emptying in Morbidly Obese Patients Undergoing Roux-en-Y Gastric Bypass: Correlation with the Occurrence of Biliary Sludge and Gallstonesen
dc.typeinfo:eu-repo/semantics/article
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