Risk Factors Associated with Outcome in Liver Retransplantation: Multicentric Study

dc.contributor.authorMattos, Rogerio Obregon de [UNIFESP]
dc.contributor.authorLinhares, Marcelo Moura [UNIFESP]
dc.contributor.authorMatos, Delcio [UNIFESP]
dc.contributor.authorAdam, Rene
dc.contributor.authorBismuth, Henri
dc.contributor.authorCastaing, Denis
dc.contributor.authorKonietzko, Achim
dc.contributor.authorLerut, Jan
dc.contributor.authorPorte, Roberti J.
dc.contributor.authorNeville, Jamieson
dc.contributor.authorAzoulay, Daniel
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHop Paul Brousse
dc.contributor.institutionUniv Paris 11
dc.contributor.institutionEssen Univ Hosp
dc.contributor.institutionBrussels St Luc Univ Hosp UCL
dc.contributor.institutionUniv Groningen
dc.contributor.institutionUniv Cambridge
dc.description.abstractBackground/Aims: To externally validate the predictive mathematical model of survival designed by Linhares et al. (2006). Methodology: This retrospective study was conducted on 217 individuals submitted to liver retransplantation from January 2000 to December 2008 in four European centers. the following variables were obtained on the recipient: age, creatinine, urgency of retransplantation and time between transplantation and retransplantation. the Kaplan-Meier survival curve and ROC curve were used to validate the mathematical model. Results: the present results showed a similar pattern of survival compared to the study of Linhares et al. (2006) concerning the biological variations, when survival curves were compared for each of the four variables analyzed between both samples. When compared, the areas below the ROC curve (aROC) of derivation (0.733) and validation samples (0.593) presented significant difference (p= 0.005), revealing low relationship of sensitivity and specificity between the two curves. Similarity was observed in Kaplan-Meier survival curves. Conclusion: This study allowed external validation by the KaplanMeier survival curves of the predictive mathematical model of survival in liver retransplantation proposed by Linhares et al. (2006). However, validation through the ROC curve, the aROC, evidenced weak discrimination ability.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg Gastroenterol, BR-04039002 São Paulo, Brazil
dc.description.affiliationHop Paul Brousse, AP HP, Hepatobiliary Ctr, Villejuif, France
dc.description.affiliationUniv Paris 11, IFR 89 9, UPRES 1596, Villejuif, France
dc.description.affiliationEssen Univ Hosp, Essen, Germany
dc.description.affiliationBrussels St Luc Univ Hosp UCL, Brussels, Belgium
dc.description.affiliationUniv Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
dc.description.affiliationUniv Cambridge, Sch Med, Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg Gastroenterol, BR-04039002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.identifier.citationHepato-gastroenterology. Athens: H G E Update Medical Publishing S A, v. 62, n. 138, p. 341-345, 2015.
dc.publisherH G E Update Medical Publishing S A
dc.rightsAcesso restrito
dc.subjectLiver retransplantationen
dc.subjectValidation modelen
dc.subjectSurvival modelen
dc.subjectSurvival rateen
dc.titleRisk Factors Associated with Outcome in Liver Retransplantation: Multicentric Studyen