Clinic-cytologic study of conjunctivochalasis and its relation to thyroid autoimmune diseases - Prospective cohort study

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dc.contributor.authorFiorentini de Almeida, Sandra Flavia
dc.contributor.authorSousa, Luciene B. de
dc.contributor.authorVieira, Luis A.
dc.contributor.authorChiamollera, Maria I.
dc.contributor.authorBarros, Jeison de N.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:23Z
dc.date.available2016-01-24T12:41:23Z
dc.date.issued2006-08-01
dc.description.abstractPurpose: To determine the prevalence of conjunctivochalasis in patients with immune thyroid diseases, to determine whether there is any association between the 2 diseases, and to determine cytologic study of conjunctivochalasis through the cytology impression test.Methods: A clinical prospective cohort study carried out by the External Diseases Department in the Ophthalmology Sector and the Thyroid Department in the Endocrinology Sector at Federal University of São Paulo (UNIFESP). the patients included were divided into 2 groups following these inclusion criteria: a control group of 25 patients without thyroid diseases, confirmed after clinical and laboratory examinations (thyroid hormones), or any other ocular diseases. the study group consisted of 31 patients with thyroid diseases, the diagnosis of which was confirmed by the Endocrinology Sector. the thyroidopathies included were autoimmune diseases but excluded nonautoimmune diseases. A protocol endorsed by the UNIFESP was followed, using clinical and ophthalmological history, biomicroscopy, and impression cytology.Results: Fifty-two percent of patients without thyroid diseases and 88% of patients with thyroid diseases presented with conjunctivochalasis. the risk ratio was 1.705 (Pr>chi(2)=0.0038), indicating that there is an association between them. for the impression cytology in inferior bulbar conjunctiva, there was an association between the result of the impression cytology and conjunctivochalasis (Pearson chi(2)=10.1190 Pr=0.006).Conclusion: the prevalence of conjunctivochalasis in patients with autoimmune thyroid diseases was 88%. Patients with autoimmune thyroidopathy presented higher percentages of conjunctivochalasis than the control group, confirming the association between them. the cytologic study showed the highest prevalence of abnormal surface features in eyes with conjunctivochalasis.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, External Dis & Cornea Serv, Paulista Med Sch, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, Ocular Dis Lab, Paulista Med Sch, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, External Dis & Cornea Serv, Paulista Med Sch, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, Ocular Dis Lab, Paulista Med Sch, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent789-793
dc.identifierhttp://dx.doi.org/10.1097/01.ico.0000226365.64796.fb
dc.identifier.citationCornea. Philadelphia: Lippincott Williams & Wilkins, v. 25, n. 7, p. 789-793, 2006.
dc.identifier.doi10.1097/01.ico.0000226365.64796.fb
dc.identifier.issn0277-3740
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29077
dc.identifier.wosWOS:000241712000006
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCornea
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectconjunctival diseaseen
dc.subjectautoimmune thyroiditidesen
dc.subjectconjunctivaen
dc.subjectcytologyen
dc.subjectthyroiden
dc.titleClinic-cytologic study of conjunctivochalasis and its relation to thyroid autoimmune diseases - Prospective cohort studyen
dc.typeinfo:eu-repo/semantics/article
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