Effects of 660 nm low-level laser therapy on muscle healing process after cryolesion

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dc.contributor.authorRodrigues, Natalia Camargo
dc.contributor.authorAssis, Livia [UNIFESP]
dc.contributor.authorFernandes, Kelly Rossetti [UNIFESP]
dc.contributor.authorMagri, Angela Maria Paiva [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.contributor.authorBrunelli, Roberta de Matos
dc.contributor.authorAbreu, Daniela Cristina Carvalho de
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2016-01-24T14:30:56Z
dc.date.available2016-01-24T14:30:56Z
dc.date.issued2013-01-01
dc.description.abstractThe aim of this study was to evaluate the effects of 660 nm low-level laser therapy (LLLT) on muscle regeneration after cryolesion in rat tibialis anterior muscle. Sixty-three Wistar rats were divided into a control group, 10 J/cm(2) laser-treated group, and 50 J/cm2 laser-treated group. Each group formed three subgroups (n = 7 per group), and the animals were sacrificed 7, 14, or 21 d after lesion. Histopathological findings revealed a lower inflammatory process in the laser-treated groups after 7 d. After 14 d, irradiated animals at both fluences showed higher granulation tissue, new muscle fibers, and organized muscle structure. After 21 d, full tissue repair was observed in all groups. Moreover, irradiated animals at both fluences showed smaller necrosis area in the first experimental period evaluated. MyoD immunoexpression was observed in both treated groups 7 d postinjury. Myogenin immunoexpression was detected after 7 and 14 d. the higher fluence increased the number of blood vessels after 14 and 21 d. These results suggest that LLLT, at both fluences, positively affects injured skeletal muscle in rats, accelerating the muscle-regeneration process.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiotherapy, BR-13560 Sao Carlos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Med Sci, Dept Surg, Campinas, SP, Brazil
dc.description.affiliationUniv São Paulo, Biomech Med & Rehabil Locomotor Syst Dept, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDCAPES: 20226300
dc.format.extent985-995
dc.identifierhttps://dx.doi.org/10.1682/JRRD.2012.08.0147
dc.identifier.citationJournal of Rehabilitation Research and Development. Baltimore: Journal Rehab Res & Dev, v. 50, n. 7, p. 985-995, 2013.
dc.identifier.doi10.1682/JRRD.2012.08.0147
dc.identifier.issn0748-7711
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35727
dc.identifier.wosWOS:000327415900014
dc.language.isoeng
dc.publisherJournal Rehab Res & Dev
dc.relation.ispartofJournal of Rehabilitation Research and Development
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnimal modelen
dc.subjectCryolesionen
dc.subjectGene expressionen
dc.subjectHistopathological analysisen
dc.subjectLaser therapyen
dc.subjectMuscle regenerationen
dc.subjectMuscle tissueen
dc.subjectMyoDen
dc.subjectMyogeninen
dc.subjectRehabilitationen
dc.titleEffects of 660 nm low-level laser therapy on muscle healing process after cryolesionen
dc.typeinfo:eu-repo/semantics/article
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