Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats
| dc.contributor.author | Rodrigues, Natalia Camargo | |
| dc.contributor.author | Brunelli, Roberta | |
| dc.contributor.author | Selistre de Araujo, Heloisa Sobreiro | |
| dc.contributor.author | Parizotto, Nivaldo Antonio | |
| dc.contributor.author | Renno, Ana Claudia Muniz [UNIFESP] | |
| dc.contributor.institution | Universidade Federal de São Carlos (UFSCar) | |
| dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | |
| dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
| dc.date.accessioned | 2016-01-24T14:31:23Z | |
| dc.date.available | 2016-01-24T14:31:23Z | |
| dc.date.issued | 2013-03-05 | |
| dc.description.abstract | Introduction: the effects of LLLT were studied during muscle regeneration through gene expression.Methods: It was evaluated 10 and 50 J/cm(2) doses during 7, 14 and 21 days post cryoinjury, through histopathological analysis and mRNA MyoD, Myogenin, Vegf and Cox-2 expression.Results: Irradiated groups presented less inflammatory process than control group after 14 and 21 days. Cox-2 levels were downregulated in all irradiated groups after 7, 14 and 21 days. On day 7, both treated groups had a downregulation of Vegf levels, and an upregulation after 14 and 21 days, mainly with 50 J/cm(2). the MyoD levels were upregulated with high dose in all periods and with low dose after 21 days. Myogenin expression was downregulated in both treated groups after 7 days, and was upregulated with 10 J/cm(2) after 21 days.Conclusion: These responses suggest that LLLT can improve the skeletal muscle regeneration through the gene expression stimulation. (C) 2013 Elsevier B.V. All rights reserved. | en |
| dc.description.affiliation | Fed Univ Sao Carlos UFSCAR, Dept Physiotherapy, BR-13565905 Sao Carlos, SP, Brazil | |
| dc.description.affiliation | Univ Estadual Campinas, Campinas UNICAMP, Dept Surg, BR-13083970 Campinas, SP, Brazil | |
| dc.description.affiliation | Fed Univ Sao Carlos UFSCAR, Dept Physiol Sci, BR-13565905 Sao Carlos, SP, Brazil | |
| dc.description.affiliation | Fed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil | |
| dc.description.affiliationUnifesp | Fed Univ São Paulo UNIFESP, Dept Biosci, Santos, SP, Brazil | |
| dc.description.source | Web of Science | |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.format.extent | 29-35 | |
| dc.identifier | https://dx.doi.org/10.1016/j.jphotobiol.2013.01.002 | |
| dc.identifier.citation | Journal of Photochemistry and Photobiology B-biology. Lausanne: Elsevier Science Sa, v. 120, p. 29-35, 2013. | |
| dc.identifier.doi | 10.1016/j.jphotobiol.2013.01.002 | |
| dc.identifier.issn | 1011-1344 | |
| dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/36077 | |
| dc.identifier.wos | WOS:000317882100004 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | Journal of Photochemistry and Photobiology B-biology | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
| dc.subject | Low-level laser therapy | en |
| dc.subject | Rat | en |
| dc.subject | Muscle repair | en |
| dc.subject | Genes expression | en |
| dc.subject | MRFs | en |
| dc.title | Low-level laser therapy (LLLT) (660 nm) alters gene expression during muscle healing in rats | en |
| dc.type | info:eu-repo/semantics/article |