Individuals with pulmonary tuberculosis have lower levels of circulating CD1d-restricted NKT cells

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Snyder-Cappione, Jennifer E.
Nixon, Douglas F.
Loo, Christopher P.
Chapman, Joan M.
Meiklejohn, Duncan A.
Melo, Fernando F.
Costa, Priscilla Ramos [UNIFESP]
Sandberg, Johan K.
Rodrigues, Denise do Socorro da Silva [UNIFESP]
Kallas, Esper Georges [UNIFESP]
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Mycobacterium tuberculosis (MTB) is a leading cause of mortality worldwide from an infectious agent. Natural killer T (NKT) cells recognize mycobacterial antigens and contribute to anti-MTB immunity in mouse models. NKT cells were measured in subjects with pulmonary tuberculosis, MTB-exposed individuals, and healthy controls. NKT cell levels are selectively lower in peripheral blood mononuclear cells from individuals with pulmonary tuberculosis than in both MTB-exposed subjects and healthy control subjects. This apparent loss of NKT cells from the peripheral blood is sustained during the 6 months after the initiation of MTB treatment. These findings indicate that NKT cells may be an important component of antituberculosis immunity.
Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 195, n. 9, p. 1361-1364, 2007.