Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress

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dc.contributor.authorMeneghini, Adriano
dc.contributor.authorFerreira, Celso [UNIFESP]
dc.contributor.authorAbreu, Luiz Carlos de
dc.contributor.authorValenti, Vitor Engrácia [UNIFESP]
dc.contributor.authorFerreira, Marcelo
dc.contributor.authorF. Filho, Celso
dc.contributor.authorMurad, Neif
dc.contributor.institutionFaculdade de Medicina do ABC Departamento de Clínica Médica
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:38:59Z
dc.date.available2015-06-14T13:38:59Z
dc.date.issued2009-01-01
dc.description.abstractOBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.en
dc.description.affiliationFaculdade de Medicina do ABC Departamento de Clínica Médica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina
dc.description.affiliationUniversidade de São Paulo Departamento de Saúde Pública
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina
dc.description.sourceSciELO
dc.format.extent921-926
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322009000900014
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009.
dc.identifier.doi10.1590/S1807-59322009000900014
dc.identifier.fileS1807-59322009000900014.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322009000900014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/4806
dc.identifier.wosWOS:000270232700014
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMemantineen
dc.subjectCardiac myocytesen
dc.subjectCardiotonic agentsen
dc.subjectCell nucleus structuresen
dc.subjectHearten
dc.titleMemantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stressen
dc.typeinfo:eu-repo/semantics/article
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