Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis

Página do item simplificado
dc.contributor.authorPereira Junior, Jose Carlos
dc.contributor.authorPradella-Hallinan, Márcia Lurdes de Cássia [UNIFESP]
dc.contributor.authorPessoa, Hugo de Lins
dc.contributor.institutionFaculdade de Medicina de Jundiaí Departamento de Pediatria
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:41:28Z
dc.date.available2015-06-14T13:41:28Z
dc.date.issued2010-01-01
dc.description.abstractData collected from medical literature indicate that dopaminergic agonists alleviate Restless Legs Syndrome symptoms while dopaminergic agonists antagonists aggravate them. Dopaminergic agonists is a physiological regulator of thyroid-stimulating hormone. Dopaminergic agonists infusion diminishes the levels of thyroid hormones, which have the ability to provoke restlessness, hyperkinetic states, tremors, and insomnia. Conditions associated with higher levels of thyroid hormones, such as pregnancy or hyperthyroidism, have a higher prevalence of Restless Legs Syndrome symptoms. Low iron levels can cause secondary Restless Legs Syndrome or aggravate symptoms of primary disease as well as diminish enzymatic activities that are involved in dopaminergic agonists production and the degradation of thyroid hormones. Moreover, as a result of low iron levels, dopaminergic agonists diminishes and thyroid hormones increase. Iron therapy improves Restless Legs Syndrome symptoms in iron deprived patients. Medical hypothesis. To discuss the theory that thyroid hormones, when not counterbalanced by dopaminergic agonists, may precipitate the signs and symptoms underpinning Restless Legs Syndrome. The main cause of Restless Legs Syndrome might be an imbalance between the dopaminergic agonists system and thyroid hormones.en
dc.description.affiliationFaculdade de Medicina de Jundiaí Departamento de Pediatria
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psicobiologia
dc.description.affiliationUnifespUNIFESP, Depto. de Psicobiologia
dc.description.sourceSciELO
dc.format.extent547-554
dc.identifierhttp://dx.doi.org/10.1590/S1807-59322010000500013
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 65, n. 5, p. 547-554, 2010.
dc.identifier.doi10.1590/S1807-59322010000500013
dc.identifier.fileS1807-59322010000500013.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322010000500013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5536
dc.identifier.wosWOS:000278959900013
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRestless Legs Syndromeen
dc.subjectRLSen
dc.subjectRLS pathophysiologyen
dc.subjectDopamineen
dc.subjectTSHen
dc.subjectCYP450en
dc.titleImbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesisen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1807-59322010000500013.pdf
Tamanho:
438.15 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos