IGG AND IGE ANTIBODY-RESPONSES TO DUST-MITE ALLERGENS AMONG CHILDREN WITH ASTHMA IN BRAZIL
Data
1993-08-01
Autores
Arruda, Luisa Karla de Paula 
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We compared exposure and levels of IgE and IgG antibodies to inhalant allergens in 20 children with asthma and positive skin tests to Dermatophagoides pteronyssinus, living in Sao Paulo, to 20 control children without history of asthma or allergy and negative skin tests to D. pteronyssinus, D. farinae, and Blomia tropicalis. In 16/20 and 17/20 houses of asthmatic and control children, respectively, at least one sample was obtained which contained > 10 mug Der p I/g of dust. Serum IgE antibodies to D. pteronyssinus and Blomia tropicalis were > 200 RAST U/mL in 19120 and in 16/20 asthmatic children, respectively. In the control group, IgE antibodies to either mite species were < 40 RAST U/mL in most cases. IgG anti-Der p I and anti-Der f I antibodies were detected in 17/20 asthmatics, as opposed to 3/20 controls. Neither cat nor cockroach allergens caused significant sensitization among asthmatic or control children. Although exposure to high levels of mite allergens was common in Sao Paulo, significant IgE and IgG antibody responses were detected only in children with asthma.
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Annals Of Allergy. Arlington Hts: Amer Coll Allergy Asthma Immunology, v. 71, n. 2, p. 152-158, 1993.