Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats

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dc.contributor.authorHosaka, E.m.
dc.contributor.authorSantos, Oscar Fernando Pavão dos [UNIFESP]
dc.contributor.authorSeguro, A.c.
dc.contributor.authorVattimo, M.f.f.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:31:11Z
dc.date.available2015-06-14T13:31:11Z
dc.date.issued2004-07-01
dc.description.abstractThe frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantly in the inflammatory process. Both are inhibited by non-selective NSAID such as indomethacin. Selective COX-2 inhibitors such as rofecoxib seem to have fewer renal side effects than non-selective inhibitors. The objective of the present study was to determine whether the combined use of rofecoxib and gentamicin can prevent the increased renal injury caused by gentamicin and indomethacin. Male Wistar rats (250-300 g) were treated with gentamicin (100 mg/kg body weight, ip, N = 7), indomethacin (5 mg/kg, orally, N = 7), rofecoxib (1.4 mg/kg, orally, N = 7), gentamicin + rofecoxib (100 and 1.4 mg/kg, respectively) or gentamicin + indomethacin (100 and 5 mg/kg, respectively, N = 8) for 5 days. Creatinine clearance and alpha-glutathione-S-transferase concentrations were used as markers of renal injury. Animals were anesthetized with ether and sacrificed for blood collection. The use of gentamicin plus indomethacin led to worsened renal function (0.199 ± 0.019 ml/min), as opposed to the absence of a nephrotoxic effect of rofecoxib when gentamicin plus rofexicob was used (0.242 ± 0.011 ml/min). These results indicate that COX-2-selective inhibitors can be used as an alternative treatment to conventional NSAID, especially in situations in which risk factors for nephrotoxicity are present.en
dc.description.affiliationUniversidade de São Paulo Escola de Enfermagem Laboratório Experimental
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Laboratório de Investigação Médica
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Clínica Médica Divisão de Nefrologia
dc.description.affiliationUnifespUNIFESP, Depto. de Clínica Médica Divisão de Nefrologia
dc.description.sourceSciELO
dc.format.extent979-985
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2004000700006
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 7, p. 979-985, 2004.
dc.identifier.doi10.1590/S0100-879X2004000700006
dc.identifier.fileS0100-879X2004000700006.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2004000700006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2154
dc.identifier.wosWOS:000222450200006
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIndomethacinen
dc.subjectRofecoxiben
dc.subjectNonsteroidal anti-inflammatory drugsen
dc.subjectAminoglycosideen
dc.subjectAcute renal failureen
dc.titleEffect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in ratsen
dc.typeinfo:eu-repo/semantics/article
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