Hippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibition

Página do item simplificado
dc.contributor.authorIssy, Ana Carolina
dc.contributor.authorFonseca, José Roberto Falco [UNIFESP]
dc.contributor.authorPardo, Luis Angel
dc.contributor.authorStuehmer, Walter
dc.contributor.authorDel Bel, Eliane Aparecida
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMax Planck Inst Expt Med
dc.date.accessioned2016-01-24T14:35:09Z
dc.date.available2016-01-24T14:35:09Z
dc.date.issued2014-01-24
dc.description.abstractRecently, our group described the ether-a-go-go1(Eag1) voltage-gated potassium (K+) channel (Kv10.1) expression in the dopaminergic cells indicating that these channels are part of the diversified group of ion channels related to dopaminergic neurons function. the increase of dopamine neurotransmission induces a reduction in the prepulse inhibition (PPI) of the acoustic startle reflex in rodents, which is a reliable index of sensorimotor gating deficits. the PPI response has been reported to be abnormally reduced in schizophrenia patients. the role of Eag1 K+ channels in the PPI reaction had not been revealed until now, albeit the singular distribution of Eag1 in the dentate gyrus of the hippocampus and the hippocampal regulation of the startle reflex and PPI. the aim of this work was to investigate if Eag1 blockade on hippocampus modifies the PPI-disruptive effects of apomorphine in Wistar rats. Bilateral injection of anti-Eag1 single-chain antibody into the dentate gyrus of hippocampus did not modify apomorphine-disruptive effects in the PPI response. However, Eag1 antibody completely restored the startle amplitude decrease revealed after dentate gyrus surgery. These potentially biological important phenomenon merits further investigation regarding the role of Eag1 K+ channels, mainly, on startle reflex modulation, since the physiological role of these channels remain obscure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14049904 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, São Paulo, Brazil
dc.description.affiliationMax Planck Inst Expt Med, Dept Mol Biol Neuronal Signals, D-37075 Gottingen, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent13-17
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2013.11.026
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 559, p. 13-17, 2014.
dc.identifier.doi10.1016/j.neulet.2013.11.026
dc.identifier.fileWOS000331021900003.pdf
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37326
dc.identifier.wosWOS:000331021900003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDopamineen
dc.subjectPrepulse inhibitionen
dc.subjectSchizophreniaen
dc.subjectEag1en
dc.subjectKv10.1en
dc.subjectStartle reflexen
dc.titleHippocampal ether-a-go-go1 potassium channels blockade: Effects in the startle reflex and prepulse inhibitionen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000331021900003.pdf
Tamanho:
1.12 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
Em verificação - Geral