Risk factors for cardiovascular disease and endothelin-1 levels in Takayasu arteritis patients
Data
2009-04-01
Autores
Souza, Alexandre Wagner Silva de 
Mariz, Henrique Ataide
Reis Neto, Edgard Torres dos
Arraes, Anne Elizabeth Diniz
Silva, Neusa Pereira da
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The objective of this study was to evaluate traditional risk factors for cardiovascular disease (CVD) and endothelin-1 (ET-1) levels in Takayasu arteritis (TA) patients. Twenty-two TA patients and 37 controls were evaluated. TA patients had a higher prevalence of hypertension (63.6% vs. 21.6%, p = 0.001) and higher levels of triglycerides (129.5 mg/dL +/- 70.8 vs. 88.4 mg/dL +/- 60.8, p = 0.017) than controls. Mean number of CVD risk factors was 1.64 +/- 1.22 in TA patients and 1.03 +/- 1.44 among controls, p = 0.030. More TA patients presented at least one CVD risk factor when compared to controls (77.2% vs. 51.3%, p = 0.048). ET-1 levels were higher in patients than in controls (1.49 pg/mL +/- 0.45 vs. 1.27 pg/mL +/- 0.32, p = 0.034), however no significant difference was found between patients with active and inactive disease. in this study, TA patients presented a higher prevalence of hypertension, higher levels of triglycerides, and ET-1 than controls.
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Clinical Rheumatology. New York: Springer, v. 28, n. 4, p. 379-383, 2009.