SARS-COV-2 em placentas sob análise histopatológica e imuno-histoquímica: uma revisão integrativa.
Data
2022
Tipo
Trabalho de conclusão de curso
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: Analisar o conhecimento produzido acerca da presença de SARS-CoV-2 em
placentas por meio de estudos histopatológicos e imuno-histoquímicos. Método:
Revisão integrativa da literatura nas bases de dados Virtual Health Library (BVS),
Scopus, PubMed, Web of Science e Scielo englobando 26 artigos. Discussão: Os
estudos incluídos apontaram achados morfológicos relacionados aos efeitos da infecção
por COVID-19 em tecidos placentários. Foram analisados casos diversos que
compreenderam efeitos deletérios na evolução das gestações, envolvendo má perfusão
fetal, necrose trofoblástica e trombos, resultando em insuficiência placentária.
Conclusão: A infecção do SARS-CoV-2 em gestantes está associada a maior incidência
de eventos inflamatórios tanto na placenta quanto no feto, principalmente devido à
afinidade do vírus com o tecido trofoblástico, aumentando assim, a susceptibilidade de
transmissão vertical.
Objective: The analysis of knowledge produced about the presence of SARS-CoV-2 in placentas by histopathological and immunohistochemical studies. Method: Integrative literature review in the Virtual Health Library (BVS), Scopus, PubMed, Web of Science and Scielo data bases, comprising 26 articles. Discussion: The included studies pointed to morphological findings related to the effects of COVID-19 infection on placental tissues. Several cases were analyzed that included deleterious effect son the evolution of pregnancies, involving poor fetal perfusion, trophoblastic necrosis and thrombi, resulting in placental insufficiency. Conclusion: SARS-CoV-2 infection in pregnant women is associated with a higher incidence inflammatory events both in the placenta and in the fetus, mainly dueto the affinity of the vírus with the trophoblastic tissue, thus increasing the susceptibility of vertical transmission.
Objective: The analysis of knowledge produced about the presence of SARS-CoV-2 in placentas by histopathological and immunohistochemical studies. Method: Integrative literature review in the Virtual Health Library (BVS), Scopus, PubMed, Web of Science and Scielo data bases, comprising 26 articles. Discussion: The included studies pointed to morphological findings related to the effects of COVID-19 infection on placental tissues. Several cases were analyzed that included deleterious effect son the evolution of pregnancies, involving poor fetal perfusion, trophoblastic necrosis and thrombi, resulting in placental insufficiency. Conclusion: SARS-CoV-2 infection in pregnant women is associated with a higher incidence inflammatory events both in the placenta and in the fetus, mainly dueto the affinity of the vírus with the trophoblastic tissue, thus increasing the susceptibility of vertical transmission.