The water supply system as a potential source of fungal infection in paediatric haematopoietic stem cell units

Página do item simplificado
dc.contributor.authorMesquita-Rocha, Sabrina [UNIFESP]
dc.contributor.authorGodoy-Martinez, Patricio C.
dc.contributor.authorGoncalves, Sarah S. [UNIFESP]
dc.contributor.authorDaniel Urrutia, Milton
dc.contributor.authorCarlesse, Fabianne [UNIFESP]
dc.contributor.authorSeber, Adriana [UNIFESP]
dc.contributor.authorSilva, Maria Aparecida Aguiar [UNIFESP]
dc.contributor.authorPetrilli, Antonio Sergio [UNIFESP]
dc.contributor.authorColombo, Arnaldo Lopes [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Austral Chile
dc.contributor.institutionUniv Antofagasta
dc.date.accessioned2016-01-24T14:31:53Z
dc.date.available2016-01-24T14:31:53Z
dc.date.issued2013-06-26
dc.description.abstractBackground: We conducted a prospective study to investigate the presence of microfungal contamination in the water supply system of the Oncology Paediatric Institute, São Paulo - Brazil after the occurrence of one invasive Fusarium solani infection in a patient after Haematopoietic Stem Cell Transplantation (HSCT). During a twelve-month period, we investigated the water supply system of the HSCT unit by monitoring a total of fourteen different collection sites.Methods: One litre of water was collected in each location, filtered through a 0.45 mu m membrane and cultured on SDA to detect the presence of filamentous fungi. Physicochemical analyses of samples were performed to evaluate the temperature, turbidity, pH, and the concentration of free residual chlorine.Results: Over the 12 months of the study, 164 samples were collected from the water supply system of the HSCT unit, and 139 of the samples tested positive for filamentous fungi (84.8%), generating a total of 2,362 colonies. Cladosporium spp., Penicillium spp., Purpureocillium spp. and Aspergillus spp. were ranked as the most commonly found genera of mould in the collected samples. of note, Fusarium solani complex isolates were obtained from 14 out of the 106 samples that were collected from tap water (mean of 20 CFU/L). There was a positive correlation between the total number of fungal CFU obtained in all cultures and both water turbidity and temperature parameters. Our findings emphasise the need for the establishment of strict measures to limit the exposure of high-risk patients to waterborne fungal propagules.Conclusions: We were able to isolate a wide variety of filamentous fungi from the water of the HSCT unit where several immunocompromised patients are assisted.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Med, Disciplina Infectol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Austral Chile, Inst Clin Microbiol, Valdivia, Chile
dc.description.affiliationUniv Antofagasta, Antofagasta, Chile
dc.description.affiliationUniversidade Federal de São Paulo, Inst Oncol Pediat, GRAACC, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Med, Disciplina Infectol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Oncol Pediat, GRAACC, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2005/02138-3
dc.description.sponsorshipIDCNPq: 133621/2007-3
dc.description.sponsorshipIDCAPES: PNPD 2312/2011
dc.description.sponsorshipIDCNPq: 150368/2005-4
dc.format.extent8
dc.identifierhttp://dx.doi.org/10.1186/1471-2334-13-289
dc.identifier.citationBmc Infectious Diseases. London: Biomed Central Ltd, v. 13, 8 p., 2013.
dc.identifier.doi10.1186/1471-2334-13-289
dc.identifier.fileWOS000321577600001.pdf
dc.identifier.issn1471-2334
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36433
dc.identifier.wosWOS:000321577600001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofBmc Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFilamentous fungien
dc.subjectNosocomial wateren
dc.subjectAspergillosisen
dc.subjectFusariosisen
dc.subjectFungal propagulesen
dc.titleThe water supply system as a potential source of fungal infection in paediatric haematopoietic stem cell unitsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000321577600001.pdf
Tamanho:
624.71 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
Em verificação - Geral