Relationship between the type of BCR-ABL rearrangement and bone marrow histopathological features in chronic myeloid leukemia
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1997-01-01
Autores
Colleoni, Gisele Wally Braga 
Silva, Maria Regina Regis
Silva, Rebeca de Souza e
Costa, Fernando Ferreira
Kerbauy, José
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The aim of the present study was to characterize the type of BCR-ABL transcript and to correlate the molecular feature with bone marrow histology. For this purpose, we analysed the BCR-ABL rearrangement in 26 patients with chronic myeloid leukemia (CML) in the chronic phase by RT-PCR, and we also classified the bone marrow histology according to the predominance of granulocylic (GRAN) or granulocytic and megakaryocytic (GRAM/MEG) proliferation, after analysis of two independent observers. We did not find any significant difference in survival of patients presenting b(2)-a(2) and b(3)-a(2) transcripts or GRAN and GRAN/MEG bone marrow types, nor did we find any significant correlation of the type of BCR-ABL transcript with the bone marrow histological subgroups GRAN and GRAN-MEG (Fisher's test = 0.31). Thus, we conclude that the presence of exon b(3) is not correlated to bone marrow histology in CML.
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Acta Oncologica. Oslo: Scandinavian University Press, v. 36, n. 3, p. 313-315, 1997.