The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment

Página do item simplificado
dc.contributor.authorSilva, Patricia Leao da [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorCheik, Nadia Carla
dc.contributor.authorSanches, Priscila Lima [UNIFESP]
dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorInoue, Daniela [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2016-01-24T14:27:02Z
dc.date.available2016-01-24T14:27:02Z
dc.date.issued2012-04-01
dc.description.abstractBACKGROUND: Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy. METHODS: Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index [BMI] 36 +/- 5 kg/m(2)) and 15 EIB (BMI 36 +/- 5 kg/m(2)), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components. RESULTS: Anthropometrics and lung function variables improved significantly after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. in addition, a low FEV1 value was a risk factor associated with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O-2 consumption values as well as the adipokines profile. CONCLUSIONS: in the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines.en
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniv Fed Uberlandia, BR-38400 Uberlandia, MG, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Nutr, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-04020060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociação Fundo de Incentivo Pesquisa (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCentro de Excelencia Esportiva (CENESP)
dc.description.sponsorshipIDFAPESP: 2008/53069-0
dc.description.sponsorshipIDFAPESP: FAPESP 2006/00684-3
dc.description.sponsorshipIDFAPESP: FAPESP 98/14303-3
dc.format.extent572-582
dc.identifierhttps://dx.doi.org/10.4187/respcare.01307
dc.identifier.citationRespiratory Care. Irving: Daedalus Enterprises Inc, v. 57, n. 4, p. 572-582, 2012.
dc.identifier.doi10.4187/respcare.01307
dc.identifier.issn0020-1324
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/34738
dc.identifier.wosWOS:000302928500010
dc.language.isoeng
dc.publisherDaedalus Enterprises Inc
dc.relation.ispartofRespiratory Care
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectObesityen
dc.subjectAdolescentsen
dc.subjectAdipokinesen
dc.subjectBronchospasmen
dc.subjectExercise-induceden
dc.subjectTreatmenten
dc.subjectInterdisciplinary studiesen
dc.titleThe Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatmenten
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos