Restoration of retinal morphology and residual scarring after photocoagulation

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dc.contributor.authorLavinsky, Daniel [UNIFESP]
dc.contributor.authorCardillo, Jose A. [UNIFESP]
dc.contributor.authorMandel, Yossi
dc.contributor.authorHuie, Philip
dc.contributor.authorMelo, Luiz A. [UNIFESP]
dc.contributor.authorFarah, Michel Eid [UNIFESP]
dc.contributor.authorBelfort, Rubens Junior [UNIFESP]
dc.contributor.authorPalanker, Daniel
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionStanford Univ
dc.date.accessioned2016-01-24T14:31:49Z
dc.date.available2016-01-24T14:31:49Z
dc.date.issued2013-06-01
dc.description.abstractAbstract.Purpose: To study healing of retinal laser lesions in patients undergoing PRP using SD-OCT.Methods: Moderate, light and barely visible retinal burns were produced in patients with proliferative diabetic retinopathy scheduled for PRP using 100-, 20- and 10-ms pulses of 532-nm laser, with retinal spot sizes of 100, 200 and 400 mu m. Lesions were measured with OCT at 1 hr, 1 week, 1, 2, 4, 6, 9 and 12 months. OCT imaging was correlated with histology in a separate study in rabbits.Results: Lesions produced by the standard 100-ms exposures exhibited steady scarring, with the damage zone stabilized after 2 months. for 400- and 200-mu m spots and 100-ms pulses, the residual scar area at 12 months was approximately 50% of the initial lesion size for moderate, light and barely visible burns. in contrast, lesions produced by shorter exposures demonstrated enhanced restoration of the photoreceptor layer, especially in smaller burns. With 20-ms pulses, the damage zone decreased to 32%, 24% and 20% for moderate, light and barely visible burns of 400 mu m, respectively, and down to 12% for barely visible burns of 200 mu m. in the 100-mu m spots, the residual scar area of the moderate 100-ms burns was 41% of the initial lesion, while barely visible 10-ms burns contracted to 6% of the initial size. Histological observations in rabbits were useful for proper interpretation of the damage zone boundaries in OCT.Conclusions: Traditional photocoagulation parameters (400 mu m, 100 ms and moderate burn) result in a stable scar similar in size to the beam diameter. Restoration of the damaged photoreceptor layer in lighter lesions produced by shorter pulses should allow reducing the common side-effects of photocoagulation such as scotomata and scarring.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationStanford Univ, Dept Ophthalmol, Stanford, CA 94305 USA
dc.description.affiliationStanford Univ, Hansen Expt Phys Lab, Stanford, CA 94305 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipPan-American Ophthalmological Foundation
dc.description.sponsorshipRetina Research Foundation
dc.format.extentE315-E323
dc.identifierhttp://dx.doi.org/10.1111/aos.12045
dc.identifier.citationActa Ophthalmologica. Hoboken: Wiley-Blackwell, v. 91, n. 4, p. E315-E323, 2013.
dc.identifier.doi10.1111/aos.12045
dc.identifier.issn1755-375X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36365
dc.identifier.wosWOS:000334387500015
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Ophthalmologica
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectoptical coherence tomographyen
dc.subjectlaser photocoagulationen
dc.subjectwound healingen
dc.subjectplasticityen
dc.titleRestoration of retinal morphology and residual scarring after photocoagulationen
dc.typeinfo:eu-repo/semantics/article
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