Neurotoxicity and aggressiveness triggered by low-level lead in children: a review

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dc.contributor.authorOlympio, Kelly Polido Kaneshiro
dc.contributor.authorGonçalves, Claudia
dc.contributor.authorGüenther, Wanda Maria Risso
dc.contributor.authorBechara, Etelvino José Henriques [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCtr Extensao Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:54:35Z
dc.date.available2018-06-18T11:54:35Z
dc.date.issued2009-09-01
dc.description.abstractLead-induced neurotoxicity acquired by low-level long-term exposure has special relevance for children. A plethora of recent reports has demonstrated a direct link between low-level lead exposure and deficits in the neurobehavioral-cognitive performance manifested from childhood through adolescence. In many studies, aggressiveness and delinquency have also been suggested as symptoms of lead poisoning. Several environmental, occupational and domestic sources of contaminant lead and consequent health risks are largely identified and understood, but the occurrences of lead poisoning remain numerous. There is an urgent need for public health policies to prevent lead poisoning so as to reduce individual and societal damages and losses. In this paper we describe unsuspected sources of contaminant lead, discuss the economic losses and urban violence possibly associated with lead contamination and review the molecular basis of lead-induced neurotoxicity, emphasizing its effects on the social behavior, delinquency and IQ of children and adolescents.en
dc.description.affiliationUniv Sao Paulo, Fac Saude Publ, Dept Saude Ambiental, Sao Paulo, Brazil
dc.description.affiliationCtr Extensao Univ, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ciencias Exatas & Terra, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent266-275
dc.identifierhttp://dx.doi.org/10.1590/S1020-49892009000900011
dc.identifier.citationRevista Panamericana De Salud Publica-pan American Journal Of Public Health. Washington: Pan Amer Health Organization, v. 26, n. 3, p. 266-275, 2009.
dc.identifier.doi10.1590/S1020-49892009000900011
dc.identifier.fileS1020-49892009000900011.pdf
dc.identifier.issn1020-4989
dc.identifier.scieloS1020-49892009000900011
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45506
dc.identifier.wosWOS:000270941500011
dc.language.isoeng
dc.publisherPan Amer Health Organization
dc.relation.ispartofRevista Panamericana De Salud Publica-pan American Journal Of Public Health
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectLead poisoningen
dc.subjectneurotoxicity syndromesen
dc.subjectoxidative stressen
dc.subjectjuvenile delinquencyen
dc.titleNeurotoxicity and aggressiveness triggered by low-level lead in children: a reviewen
dc.title.alternativeNeurotoxicidad y agresividad desencadenadas por bajos niveles de plomo en niños: una revisiónes
dc.typeinfo:eu-repo/semantics/article
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