Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes

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dc.citation.issue21
dc.citation.volume594
dc.contributor.authorSá, Roberta Dourado Cavalcante da Cunha de [UNIFESP]
dc.contributor.authorCrisma, Amanda R.
dc.contributor.authorCruz, Maysa Mariana [UNIFESP]
dc.contributor.authorMartins, Amanda R.
dc.contributor.authorMasi, Laureane N.
dc.contributor.authordo Amaral, Catia L.
dc.contributor.authorCuri, R.
dc.contributor.authorAlonso-Vale, Maria Isabel Cardoso [UNIFESP]
dc.coverageHoboken
dc.date.accessioned2020-07-31T12:47:29Z
dc.date.available2020-07-31T12:47:29Z
dc.date.issued2016
dc.description.abstractIn the present study, we investigated the effect of fish oil (FO) on metabolism and adipokine production by adipocytes from s.c. (inguinalen
dc.description.abstractING) and visceral (retroperitonealen
dc.description.abstractRP) white adipose depots in high-fat (HF) diet-induced obese mice. Mice were divided into CO (control diet), CO+FO, HF and HF+FO groups. The HF group presented higher body weight, glucose intolerance, insulin resistance, higher plasma total and low-density lipoprotein cholesterol levels, and greater weights of ING and RP adipose depots accompanied by hypertrophy of the adipocytes. FO exerted anti-obesogenic effects associated with beneficial effects on dyslipidaemia and insulin resistance in mice fed a HF diet (HF+FO group). HF raised RP adipocyte lipolysis and the production of pro-inflammatory cytokines and reduced de novo synthesis of fatty acids, whereas, in ING adipocytes, it decreased glucose uptake and adiponectin secretion but did not change lipolysis. Therefore, the adipose depots play different roles in HF diet-induced insulin resistance according to their location in the body. Concerning cytokine secretion, adipocytes per se in addition to white adopise tissue infiltrated leukocytes have to be considered in the aetiology of the comorbidities associated with obesity. Evidence is presented showing that previous and concomitant administration of FO can prevent changes in metabolism and the secretion of hormones and cytokines in ING and RP adipocytes induced by HF.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biol Sci, Inst Environm Sci Chem & Pharmaceut, 210 Sao Nicolau St, BR-09913030 Diadema, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, Brazil
dc.description.affiliationState Univ Goias, Campus Exact Sci & Technol, Anapolis, Brazil
dc.description.affiliationUnifespDepartment of Biological Sciences, Institute of Environmental Sciences, Chemical and Pharmaceutical, Universidade Federal de São Paulo (UNIFESP), Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipGuggenheim Foundation
dc.description.sponsorshipIDFAPESP: 2011/51627-8
dc.description.sponsorshipIDFAPESP: 2010/07596-8
dc.description.sponsorshipIDFAPESP: 2010/05669-8
dc.description.sponsorshipIDFAPESP: 2013/03268-4
dc.format.extent6301-6317
dc.identifierhttp://dx.doi.org/10.1113/JP272541
dc.identifier.citationJournal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6301-6317, 2016.
dc.identifier.doi10.1113/JP272541
dc.identifier.issn0022-3751
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56847
dc.identifier.wosWOS:000387084200019
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal Of Physiology-London
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleFish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytesen
dc.typeinfo:eu-repo/semantics/article
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