Revisiting mouse peritoneal macrophages: heterogeneity, development, and function

dc.contributor.authorCassado, Alexandra dos Anjos
dc.contributor.authorD'Imperio Lima, Maria Regina
dc.contributor.authorBortoluci, Karina Ramalho [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:40:31Z
dc.date.available2016-01-24T14:40:31Z
dc.date.issued2015-05-19
dc.description.abstractTissue macrophages play a crucial role in the maintenance of tissue homeostasis and also contribute to inflammatory and reparatory responses during pathogenic infection and tissue injury. the high heterogeneity of these macrophages is consistent with their adaptation to distinct tissue environments and specialization to develop niche-specific functions. Although peritoneal macrophages are one of the best-studied macrophage populations, recently it was demonstrated the co-existence of two subsets in mouse peritoneal cavity (PerC), which exhibit distinct phenotypes, functions, and origins. These macrophage subsets have been classified, according to their morphology, as large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs). LPMs, the most abundant subset under steady state conditions, express high levels of F4/80 and low levels of class II molecules of the major histocompatibility complex (MHC). LPMs appear to be originated from embryogenic precursors, and their maintenance in PerC is regulated by expression of specific transcription factors and tissue-derived signals. Conversely, SPMs, a minor subset in unstimulated PerC, have a F4/80(low)MHC-IIhigh phenotype and are generated from bone-marrow-derived myeloid precursors. in response to infectious or inflammatory stimuli, the cellular composition of PerC is dramatically altered, where LPMs disappear and SPMs become the prevalent population together with their precursor, the inflammatory monocyte. SPMs appear to be the major source of inflammatory mediators in PerC during infection, whereas LPMs contribute for gut-associated lymphoid tissue-independent and retinoic acid-dependent IgA production by peritoneal B-1 cells. in the previous years, considerable efforts have been made to broaden our understanding of LPM and SPM origin, transcriptional regulation, and functional profile. This review addresses these issues, focusing on the impact of tissue-derived signals and external stimulation in the complex dynamics of peritoneal macrophage populations.en
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, CTC Mol, São Paulo, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, CTC Mol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ciencias Biol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipINCTV
dc.description.sponsorshipIDFAPESP: 2013/16010-5
dc.description.sponsorshipIDFAPESP: 2013/07140-2
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.3389/fimmu.2015.00225
dc.identifier.citationFrontiers in Immunology. Lausanne: Frontiers Research Foundation, v. 6, 9 p., 2015.
dc.identifier.doi10.3389/fimmu.2015.00225
dc.identifier.fileWOS000355324500001.pdf
dc.identifier.issn1664-3224
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39108
dc.identifier.wosWOS:000355324500001
dc.language.isoeng
dc.publisherFrontiers Research Foundation
dc.relation.ispartofFrontiers in Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectperitoneal macrophagesen
dc.subjectperitoneal cavityen
dc.subjectLPMen
dc.subjectSPMen
dc.subjectoriginen
dc.titleRevisiting mouse peritoneal macrophages: heterogeneity, development, and functionen
dc.typeinfo:eu-repo/semantics/article
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