Restless Legs Syndrome and Pain Disorders: What's in common?

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dc.contributor.authorGoulart, Leonardo Ierardi
dc.contributor.authorDelgado Rodrigues, Raimundo Nonato
dc.contributor.authorPeres, Mario Fernando Prieto [UNIFESP]
dc.contributor.institutionHosp Israelita Albert Einstein
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:04Z
dc.date.available2016-01-24T14:38:04Z
dc.date.issued2014-11-01
dc.description.abstractBetween 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an urge to move frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. the potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.en
dc.description.affiliationHosp Israelita Albert Einstein, Dept Neurofisiol Clin, BR-05652900 São Paulo, Brazil
dc.description.affiliationUniv Brasilia, Fac Med, BR-70844110 Brasilia, DF, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, BR-05652900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Fac Med ABC FMABC, BR-05652900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Fac Med ABC FMABC, BR-05652900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.1007/s11916-014-0461-0
dc.identifier.citationCurrent Pain and Headache Reports. New York: Springer, v. 18, n. 11, 11 p., 2014.
dc.identifier.doi10.1007/s11916-014-0461-0
dc.identifier.issn1531-3433
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38384
dc.identifier.wosWOS:000342443900005
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCurrent Pain and Headache Reports
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectSleep disordersen
dc.subjectChronic painen
dc.subjectRestless legs syndromeen
dc.subjectWillis-Ekbom diseaseen
dc.subjectPeriodic leg movementen
dc.subjectDysesthesiasen
dc.subjectCircadianen
dc.subjectDopamineen
dc.subjectOpioiden
dc.subjectSerotoninen
dc.subjectGlutamateen
dc.subjectIronen
dc.subjectGamma-aminobutyric aciden
dc.subjectVitamin Den
dc.subjectMelatoninen
dc.subjectFibromyalgiaen
dc.subjectMigraineen
dc.subjectPeripheral neuropathyen
dc.subjectSomatoform pain disorderen
dc.subjectNeuropathic painen
dc.subjectDopaminergic agonistsen
dc.subjectGabapentinen
dc.subjectPregabalinen
dc.subjectBenzodiazepinesen
dc.titleRestless Legs Syndrome and Pain Disorders: What's in common?en
dc.typeinfo:eu-repo/semantics/article
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