Description and evaluation of experimental models for uterine transplantation in pigs
dc.citation.issue | 4 | |
dc.citation.volume | 15 | |
dc.contributor.author | de Oliveira, Emerson | |
dc.contributor.author | da Silva Tavares, Kelly Alessandra | |
dc.contributor.author | Vieira Gomes, Mariano Tamura | |
dc.contributor.author | Salzedas-Netto, Alcides Augusto [UNIFESP] | |
dc.contributor.author | Ferreira Sartori, Marair Gracio [UNIFESP] | |
dc.contributor.author | Castro, Rodrigo Aquino [UNIFESP] | |
dc.contributor.author | Fernandes, Cesar Eduardo | |
dc.contributor.author | Batista Castello Girao, Manoel Joao [UNIFESP] | |
dc.coverage | Sao Paulo Sp | |
dc.date.accessioned | 2020-08-04T13:39:54Z | |
dc.date.available | 2020-08-04T13:39:54Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Objective: To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression. Methods: We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood incompatibility. Hysterectomy was performed in the donor under general anesthesia, with the removal of the aorta and inferior vena cava in monobloc, and anastomosis of these vessels was made in the recipient. Results: Six experiments were performed, and on the immediate postoperative period, five animals had good reperfusion. However, on the seventh postoperative day, histological analysis showed rejection in five animals. Conclusion: The experimental model of uterine transplantation is feasible, but monitoring doses of immunosuppressants is pivotal to prevent rejection episodes. | en |
dc.description.abstract | Objetivo: Avaliar a técnica de transplante uterino e o uso de drogas no processo de imunossupressão. Métodos: Foram incluídas 12 porcas, sendo realizada imunossupressão com doses mínimas de ciclosporina, e prova cruzada para afastar a possibilidade de incompatibilidade sanguínea. Realizou-se, na doadora, histerectomia sob anestesia geral, com a retirada, em monobloco, da aorta e da veia cava inferior, de tal forma que, na receptora, fosse possível realizar a anastomose com estes vasos. Resultados: Foram realizados seis experimentos e, no pós-operatório imediato, houve boa reperfusão em cinco animais. Entretanto, no sétimo dia de pós-operatório, as análises histológicas demonstraram rejeição em cinco deles. Conclusão: O modelo experimental de transplante uterino é factível, mas a monitorização das doses de imunossupressores é importante, a fim de impedir os episódios de rejeição. | pt |
dc.description.affiliation | ABC, Fac Med, Santo Andre, SP, Brazil | |
dc.description.affiliation | Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil | |
dc.description.affiliation | Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil | |
dc.description.affiliationUnifesp | Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Fundacao de Amparo a Pesquisa de Estado de Sao Paulo (FAPESP) | |
dc.description.sponsorshipID | FAPESP: 2008/09441-1 | |
dc.format.extent | 481-485 | |
dc.identifier | http://dx.doi.org/10.1590/S1679-45082017AO4066 | |
dc.identifier.citation | Einstein-Sao Paulo. Sao Paulo Sp, v. 15, n. 4, p. 481-485, 2017. | |
dc.identifier.doi | 10.1590/S1679-45082017AO4066 | |
dc.identifier.file | S1679-45082017000400481-en.pdf | |
dc.identifier.file | S1679-45082017000400481-pt.pdf | |
dc.identifier.issn | 1679-4508 | |
dc.identifier.scielo | S1679-45082017000400481 | |
dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/57176 | |
dc.identifier.wos | WOS:000423856800017 | |
dc.language.iso | eng | |
dc.language.iso | por | |
dc.publisher | Inst Israelita Ensino & Pesquisa Albert Einstein | |
dc.relation.ispartof | Einstein-Sao Paulo | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Transplantation | en |
dc.subject | Uterus/transplantation | en |
dc.subject | Infertility | en |
dc.subject | Pregnancy | en |
dc.subject | Swine | en |
dc.subject | Models | en |
dc.subject | animal | en |
dc.subject | Immunosuppressive agents | en |
dc.subject | Cyclosporine | en |
dc.subject | Transplante | pt |
dc.subject | Útero/transplante | pt |
dc.subject | Infertilidade | pt |
dc.subject | Gravidez | pt |
dc.subject | Suínos | pt |
dc.subject | Modelos animais | pt |
dc.subject | Imunossupressores | pt |
dc.subject | Ciclosporina | pt |
dc.title | Description and evaluation of experimental models for uterine transplantation in pigs | en |
dc.title.alternative | Descrição e avaliação de modelos experimentais para transplante uterino em suínos | pt |
dc.type | info:eu-repo/semantics/article |