3q27 Aberrations in a Childhood Ovary Teratoma With Associated Malignant Germ Cell Component
Data
2009-03-01
Tipo
Artigo
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Resumo
Cytogenetic Studies of childhood ovary tumors have been poorly described. in the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk-sac) component occurring in an 8-year-old female are detailed. GTG-banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) [4]/46,XX, del3q27 [3]/46,XX [30]. Previous Studies have demonstrated common sites of loss of heterozygosity at 3q27-q28 region in different types of cancer, suggesting the presence of tumor Suppressor genes within this region. Pediatr Blood Cancer 2009;52:398-401. (C) 2008 Wiley-Liss, Inc.
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Citação
Pediatric Blood & Cancer. Hoboken: Wiley-liss, v. 52, n. 3, p. 398-401, 2009.