Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian Study

dc.contributor.authorGales, Ana Cristina [UNIFESP]
dc.contributor.authorAzevedo, Heber Dias
dc.contributor.authorCereda, Rosangela Ferraz [UNIFESP]
dc.contributor.authorGirardello, Raquel [UNIFESP]
dc.contributor.authorXavier, Danilo Elias [UNIFESP]
dc.contributor.authorINVITA-A-DORI Brazilian Study Grp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T14:04:33Z
dc.date.available2018-06-15T14:04:33Z
dc.date.issued2011-11-01
dc.description.abstractIn vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intra-abdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was used for interpretation of the antimicrobial susceptibility results. Doripenem was as active as meropenem and more active than imipenem against E. coli and K. pneumoniae isolates. A total of 50.0% of Enterobacter spp. isolates were resistant to ceftazidime but 85.7% of them were inhibited at doripenem MICs <= 1 mu g/mL. Polymyxin B was the only agent to show potent activity against Acinetobacter spp. (MIC50/90, <= 0.5/1 mu g/mL) and P. aeruginosa (MIC50/90, 1/2 mu g/mL). Although high rates of imipenem (53.1%) and meropenem (44.5%) resistance were detected among P aeruginosa, doripenem showed MIC50 of 16 mu g/mL against imipenem-resistant P aeruginosa and inhibited a greater number of imipenem-resistant P aeruginosa (10.5%) at MIC values of <= 4 mu g/mL than did meropenem (0.0%). In this study, doripenem showed similar in vitro activity to that of meropenem and retained some activity against imipenem-resistant P aeruginosa isolated from Brazilian medical centers.en
dc.description.affiliationEPM UNIFESP, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespEPM UNIFESP, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipJanssen-Cilag
dc.description.sponsorshipPfizer
dc.description.sponsorshipNovartis
dc.description.sponsorshipSanofi-Aventis
dc.format.extent513-520
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702011000600003
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Amsterdam: Elsevier Science Bv, v. 15, n. 6, p. 513-520, 2011.
dc.identifier.doi10.1590/S1413-86702011000600003
dc.identifier.fileS1413-86702011000600003.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702011000600003
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42878
dc.identifier.wosWOS:000298304300002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsAcesso aberto
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectcarbapenemsen
dc.subjectGram-negative bacteriaen
dc.subjectBrazilen
dc.titleAntimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian Studyen
dc.typeArtigo
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