Administration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effects

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dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.contributor.authorHagemann, Cristiane Cadore de Farias [UNIFESP]
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorCarvalho, Adelino Moreira de [UNIFESP]
dc.contributor.authorOliveira-Filho, Ricardo Martins [UNIFESP]
dc.contributor.authorEspiridião, Silvia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionJose do Rosario Vellano Univ
dc.contributor.institutionABC Med Fdn FUABC
dc.date.accessioned2018-06-15T16:52:39Z
dc.date.available2018-06-15T16:52:39Z
dc.date.issued2013-01-01
dc.description.abstractPurpose: To evaluate the effects of the association of lopinavir and ritonavir administered during the whole period of rat pregnancy. Methods: 62 Wistar rats of the EPM-1 variant weighing about 200 g were randomly divided into five groups: two controls (Ctr1 = stress control, n = 10; and Ctr2 = drug vehicle control, n = 10) and three experimental ones which were treated with an oral solution of lopinavir/ritonavir (Exp1 = 12.8/3.2 mg/kg b.w., n = 14; Exp2 = 38.4/9.6 mg/kg b.w., n = 14; Exp3 = 115.2/28.8 mg/kg b.w., n = 14) from 'day 0' up to the 20th day of pregnancy. Maternal body weight was recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day), upon laparotomy and hysterotomy, the rats were anesthetized and the amount of implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were recorded. The collected fetuses and placentae were weighed and the concepts were examined under a stereoscope microscope for external malformations. Results: An apparent dose-unrelated lethal effect of the antiviral association on the pregnant rats was observed; notwithstanding, the body weight gain of the surviving rats had no changes, independent of the considered group. It was noted that the quantitative and qualitative intrauterine content of living term rats was indistinguishable from that of the controls. Conclusion: There was some degree of deleterious effects of the administration of the lopinavir/ritonavir association on pregnant rats; such effects eventually led to maternal death. However, neither the surviving rats showed toxicity nor did their concepts present any detectable change which could be related to the drug association.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sch Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med FMUSP, Sao Paulo, Brazil
dc.description.affiliationJose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, Brazil
dc.description.affiliationSao Paulo Univ USP, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sch Med UNIFESP EPM, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent151-154
dc.identifierhttp://www.irog.net/download/?magazine=111
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 40, n. 1, p. 151-154, 2013.
dc.identifier.issn0390-6663
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43296
dc.identifier.wosWOS:000315752800040
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRaten
dc.subjectPregnancyen
dc.subjectLopinaviren
dc.subjectRitonaviren
dc.titleAdministration of lopinavir/ritonavir association during rat pregnancy: maternal and fetal effectsen
dc.typeinfo:eu-repo/semantics/article
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