Electrophysiological correlates of sleep disturbance induced by acute and chronic administration of D-amphetamine

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dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorMargis, Regina
dc.contributor.authorFrey, Benicio N.
dc.contributor.authorGiglio, Larriany M. F.
dc.contributor.authorKapczinski, Flavio
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionMcMaster Univ
dc.date.accessioned2016-01-24T13:52:11Z
dc.date.available2016-01-24T13:52:11Z
dc.date.issued2009-01-16
dc.description.abstractSleep disturbance is the strongest predictor of manic relapse and is considered one of the most important objective measures of treatment response in bipolar disorder (BD). However, the neurobiological mechanisms underlying sleep disturbance in BD are poorly understood. the administration of psycho stimulants to rodents can trigger a number of manic-like behaviors. Therefore, the present study aims to investigate the effects of single and repeated D-amphetamine (AMPH) administration on sleep patterns in rats. Sleep was continuously monitored during light periods after single and repeated (7 days) injections of AMPH (2 mg/kg, i.p.) or saline in adult Wistar rats using electrocorticogram and electromyographic recordings. Acute injections of AMPH suppressed sleep for the first 2 h, and were followed by a gradual increase in the amount of sleep. Both slow wave sleep (SWS) and paradoxical sleep (PS) were compromised. Repeated exposure to AMPH led to a drastic disruption of the sleep-wake cycle that was mainly characterized by a decrease of PS during all time-points recorded in comparison to the saline group. Furthermore, both acute and chronic AMPH administration induced longer latencies to both SWS and PS. These findings suggest that AMPH produces profound sleep disturbances and decreases PS sleep. Given that some of these abnormalities are observed in individuals with BD, this animal model can provide a means to investigate neurobiological aspects of sleep disturbance in BD, as well as their response to mood stabilizers. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Bipolar Disorders Program, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Lab Mol Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationMcMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo Psiciofarmacologia (AFIP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao de Amparo Pesquisa do Estado de São Paulo (CEPID
dc.description.sponsorshipIDFundacao de Amparo Pesquisa do Estado de São Paulo (CEPID: 98/14303-3
dc.format.extent162-172
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2008.10.023
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1249, p. 162-172, 2009.
dc.identifier.doi10.1016/j.brainres.2008.10.023
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31252
dc.identifier.wosWOS:000263094400017
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectSleepen
dc.subjectAmphetamineen
dc.subjectAnimal modelen
dc.subjectBipolar disorderen
dc.subjectManiaen
dc.subjectSleep deprivationen
dc.subjectEEGen
dc.subjectRaten
dc.titleElectrophysiological correlates of sleep disturbance induced by acute and chronic administration of D-amphetamineen
dc.typeinfo:eu-repo/semantics/article
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