The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis

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dc.contributor.authorEsporcatte, Bruno L. B. [UNIFESP]
dc.contributor.authorKara-Jose, Andrea C. [UNIFESP]
dc.contributor.authorMelo, Luiz Alberto S., Jr. [UNIFESP]
dc.contributor.authorPinto, Luciano M. [UNIFESP]
dc.contributor.authorTavares, Ivan M. [UNIFESP]
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:34Z
dc.date.available2020-07-17T14:03:34Z
dc.date.issued2017
dc.description.abstractPurpose. To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). Methods. Healthy individuals and glaucoma patients were included in this cross-sectional study. All eyes underwent 24-2 SITA SAP and structural imaging tests. RGC count estimates were obtained using a previously described algorithm, which combines estimates of RGC numbers from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer (RNFL) average thickness. Results. A total of 119 eyes were evaluated, including 75 eyes of 48 healthy individuals and 44 eyes of 29 glaucoma patients. RGC count estimates performed better than data derived from SD-OCT RNFL average thickness or SAP mean deviation alone (area under ROC curves: 0.98, 0.92, and 0.79en
dc.description.abstractP < 0 001) for discriminating healthy from glaucomatous eyes, even in a subgroup of eyes with mild disease (0.97, 0.88, and 0.75en
dc.description.abstractP < 0 001). There was a strong and significant correlation between estimates of RGC numbers derived from SAP and SD-OCT (R-2 = 0 74en
dc.description.abstractP < 0 001). Conclusion. RGC count estimates obtained by combined structural and functional data showed excellent diagnostic accuracy for discriminating the healthy from the glaucomatous eyes and performed better than isolated structural and functional parameters.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES/Ministry of Education of Brazil
dc.description.sponsorshipCNPq/Ministry of Science and Technology of Brazil
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/2724312
dc.identifier.citationJournal Of Ophthalmology. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/2724312
dc.identifier.fileWOS000407287700001.pdf
dc.identifier.issn2090-004X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55503
dc.identifier.wosWOS:000407287700001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofJournal Of Ophthalmology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosisen
dc.typeinfo:eu-repo/semantics/article
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