Physical characterization of multiparticulate systems

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dc.citation.issue4
dc.citation.volume53
dc.contributor.authorIssa, Michele Georges
dc.contributor.authorde Souza, Natalia Vieira
dc.contributor.authorDuque, Marcelo Dutra [UNIFESP]
dc.contributor.authorFerraz, Humberto Gomes
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:03:17Z
dc.date.available2020-07-17T14:03:17Z
dc.date.issued2017
dc.description.abstractThe search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the ensuing stages of manufacture, as well as the final product. Therefore, the characterization of these small units is of fundamental importance for achieving batch homogeneity and optimal product performance. Analyses, including particle size distribution, morphology, density, porosity, mechanical strength and disintegration, are example tests used in this characterization. The objective of this review was to address the most widely used tests for the physical evaluation of multiparticulate systems.en
dc.description.affiliationUniv Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Pharmaceut Sci, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1590/s2175-97902017000400216
dc.identifier.citationBrazilian Journal Of Pharmaceutical Sciences. Sao Paulo, v. 53, n. 4, p. -, 2017.
dc.identifier.doi10.1590/s2175-97902017000400216
dc.identifier.fileS1984-82502017000400403.pdf
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502017000400403
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55281
dc.identifier.wosWOS:000431767900001
dc.language.isoeng
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMultiparticulate systems/physical characterizationen
dc.subjectPelletsen
dc.subjectGranulesen
dc.subjectMinitabletsen
dc.titlePhysical characterization of multiparticulate systemsen
dc.typeinfo:eu-repo/semantics/article
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