Sentinel lymph node in endometrial cancer

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dc.contributor.authorLopes, L. A. F.
dc.contributor.authorNicolau, S. M.
dc.contributor.authorBaracat, F. F.
dc.contributor.authorBaracat, E. C.
dc.contributor.authorGoncalves, Wagner Jose [UNIFESP]
dc.contributor.authorSantos, H. V. B.
dc.contributor.authorLopes, R. G.
dc.contributor.authorLippi, U. G.
dc.contributor.institutionHosp Servidor Publ Estadual São Paulo Francisco M
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:05Z
dc.date.available2016-01-24T13:49:05Z
dc.date.issued2007-09-01
dc.description.abstractThe aim of this study was to evaluate the possibility of identifying the sentinel lymph node and involvement of neoplastic cells in patients with endometrial carcinoma limited to the uterus, and also its correlation with the conditions of other pelvic and para-aortic lymph nodes. Forty patients with endometrial carcinoma, clinical staging I and II, were submitted to complete surgical staging through laparotomy, as recommended by FIGO in 1988. the sentinel node was investigated using patent blue dye in the myometrial subserosa. the sentinel node was excised and submitted to frozen section examination of specimen, stained with hematoxylin and eosin (H&E). Afterward, selective bilateral para-aortic and pelvic lymphadenectomy, total hysterectomy with bilateral salpingo-oophorectomy were performed. the lymph nodes excised were examined by means of paraffin-embedded slices stained with H&E and of imunohistochemistry with antikeratin antibody AE1/AE3. the sentinel lymph node was identified in 77.5% of patients (31/40), and 16.1% (5/31) presented neoplastic involvement in the node. in 25 cases of negative sentinel node, 96% (24/25) had no neoplastic involvement, and 4% (1/25) had other lymph node affected (false negative). in nine cases with no sentinel node identified, 55.5% (5/9) had lymph node involvement. the results of this study allow us to conclude that it is possible to identify the sentinel node using the methods described, and the pathologic examination significantly represents the same conditions of other pelvic and para-aortic lymph nodes.en
dc.description.affiliationHosp Servidor Publ Estadual São Paulo Francisco M, Dept Obstet & Gynecol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.affiliationHosp Servidor Publ Estadual São Paulo Francisco M, Dept Pathol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1113-1117
dc.identifierhttp://dx.doi.org/10.1111/j.1525-1438.2007.00909.x
dc.identifier.citationInternational Journal of Gynecological Cancer. Oxford: Blackwell Publishing, v. 17, n. 5, p. 1113-1117, 2007.
dc.identifier.doi10.1111/j.1525-1438.2007.00909.x
dc.identifier.issn1048-891X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30034
dc.identifier.wosWOS:000249487500024
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofInternational Journal of Gynecological Cancer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectendometrial carcinomaen
dc.subjectlymph node excisionen
dc.subjectsentinel lymph nodeen
dc.titleSentinel lymph node in endometrial canceren
dc.typeinfo:eu-repo/semantics/article
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