Lower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease

Página do item simplificado
dc.contributor.authorNdhlovu, L. C.
dc.contributor.authorSnyder-Cappione, J. E.
dc.contributor.authorCarvalho, Karina Inacio [UNIFESP]
dc.contributor.authorLeal, F. E.
dc.contributor.authorLoo, C. P.
dc.contributor.authorBruno, F. R.
dc.contributor.authorJha, A. R.
dc.contributor.authorDevita, D.
dc.contributor.authorHasenkrug, A. M.
dc.contributor.authorBarbosa, H. M. R. [UNIFESP]
dc.contributor.authorSegurado, A. C.
dc.contributor.authorNixon, D. F.
dc.contributor.authorMurphy, E. L.
dc.contributor.authorKallas, Esper Georges [UNIFESP]
dc.contributor.institutionUniv Calif San Francisco
dc.contributor.institutionBlood Syst Res Inst
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:58:56Z
dc.date.available2016-01-24T13:58:56Z
dc.date.issued2009-12-01
dc.description.abstractHuman T lymphotropic virus type 1 (HTLV-1) infects 10-20 million people worldwide. the majority of infected individuals are asymptomatic; however, approximately 3% develop the debilitating neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). There is also currently no cure, vaccine or effective therapy for HTLV-1 infection, and the mechanisms for progression to HAM/TSP remain unclear. NK T cells are an immunoregulatory T cell subset whose frequencies and effector functions are associated critically with immunity against infectious diseases. We hypothesized that NK T cells are associated with HAM/TSP progression. We measured NK T cell frequencies and absolute numbers in individuals with HAM/TSP infection from two cohorts on two continents: São Paulo, Brazil and San Francisco, CA, USA, and found significantly lower levels when compared with healthy subjects and/or asymptomatic carriers. Also, the circulating NK T cell compartment in HAM/TSP subjects is comprised of significantly more CD4(+) and fewer CD8(+) cells than healthy controls. These findings suggest that lower numbers of circulating NK T cells and enrichment of the CD4(+) NK T subset are associated with HTLV-1 disease progression.en
dc.description.affiliationUniv Calif San Francisco, Dept Med, Div Expt Med, San Francisco, CA 94110 USA
dc.description.affiliationUniv Calif San Francisco, Dept Lab Med, San Francisco, CA 94110 USA
dc.description.affiliationBlood Syst Res Inst, San Francisco, CA USA
dc.description.affiliationUniv São Paulo, Sch Med, Div Clin Immunol & Allergy, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Infect Dis, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases
dc.description.sponsorshipNational Heart Lung and Blood Institute
dc.description.sponsorshipAIDS Research Institute of University of California San Francisco
dc.description.sponsorshipBrazilian Program for STD and AIDS
dc.description.sponsorshipMinistry of Health
dc.description.sponsorshipSão Paulo City Health Department
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipJohn E. Fogarty International Center
dc.description.sponsorshipIDNational Institute of Allergy and Infectious Diseases: R37AI052731
dc.description.sponsorshipIDNational Heart Lung and Blood Institute: 2R01-HL-62235
dc.description.sponsorshipIDMinistry of Health: 914/BRA/3014 -UNESCO/Kallas
dc.description.sponsorshipIDSão Paulo City Health Department: 2004-0.168.922-7/Kallas
dc.description.sponsorshipIDFAPESP: 04/15856-9/Kallas
dc.description.sponsorshipIDJohn E. Fogarty International Center: D43 TW00003
dc.format.extent294-299
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2249.2009.04019.x
dc.identifier.citationClinical and Experimental Immunology. Malden: Wiley-Blackwell Publishing, Inc, v. 158, n. 3, p. 294-299, 2009.
dc.identifier.doi10.1111/j.1365-2249.2009.04019.x
dc.identifier.issn0009-9104
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31961
dc.identifier.wosWOS:000271311200006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical and Experimental Immunology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectCD8en
dc.subjectHTLV-1 infectionen
dc.subjectinnate immunityen
dc.subjectNK T cellsen
dc.subjectCD4en
dc.titleLower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological diseaseen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
Em verificação - Geral