Cognition and biomarkers of oxidative stress in obstructive sleep apnea

Página do item simplificado
dc.contributor.authorSales, Leticia Viana
dc.contributor.authorBruin, Veralice Meireles Sales de [UNIFESP]
dc.contributor.authorD'Almeida, Vânia [UNIFESP]
dc.contributor.authorPompéia, Sabine [UNIFESP]
dc.contributor.authorBueno, Orlando Francisco Amodeo [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorBittencourt, Lia Rita Azeredo [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do Ceará (UFC) Faculdade de Medicina
dc.date.accessioned2015-06-14T13:45:23Z
dc.date.available2015-06-14T13:45:23Z
dc.date.issued2013-04-01
dc.description.abstractOBJECTIVES: The aim of this study was to investigate neuropsychological performance and biomarkers of oxidative stress in patients with obstructive sleep apnea and the relationships between these factors. METHODS: This was an observational, cross-sectional study of 14 patients (36.0±6.5 years old) with obstructive sleep apnea and 13 controls (37.3±6.9 years old). All of the participants were clinically evaluated and underwent full-night polysomnography as well as neuropsychological tests. Blood samples were used to assay superoxide dismutase, catalase, glutathione and homocysteine, as well as vitamins E, C, B11 and B12. RESULTS: The patients performed poorly relative to the controls on several neuropsychological tests, such as the attention test and tests of long-term memory and working memory/executive function. They also had lower levels of vitamin E (p<0.006), superoxide dismutase (p<0.001) and vitamin B11 (p<0.001), as well as higher concentrations of homocysteine (p<0.02). Serum concentrations of vitamin C, catalase, glutathione and vitamin B12 were unaltered. Vitamin E levels were related to performance in the backward digit span task (F = 15.9; p = 0.002) and this correlation remained after controlling for age and body mass index (F = 6.3, p = 0.01). A relationship between superoxide dismutase concentrations and executive non-perseveration errors in the Wisconsin Card Sorting Test (F = 7.9; p = 0.01) was also observed. CONCLUSIONS: Decreased levels of antioxidants and lower performance on the neuropsychological tasks were observed in patients with obstructive sleep apnea. This study suggests that an imbalance between antioxidants and pro-oxidants may contribute to neuropsychological alterations in this patient population.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Psicobiologia
dc.description.affiliationUniversidade Federal do Ceará (UFC) Faculdade de Medicina
dc.description.affiliationUnifespUNIFESP, Depto. de Psicobiologia
dc.description.sourceSciELO
dc.description.sponsorshipAFIP
dc.description.sponsorshipFAPESP/CEPID
dc.description.sponsorshipMCT/CNPq
dc.format.extent449-455
dc.identifierhttp://dx.doi.org/10.6061/clinics/2013(04)03
dc.identifier.citationClinics. Faculdade de Medicina / USP, v. 68, n. 4, p. 449-455, 2013.
dc.identifier.doi10.6061/clinics/2013(04)03
dc.identifier.fileS1807-59322013000400449.pdf
dc.identifier.issn1807-5932
dc.identifier.scieloS1807-59322013000400449
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7719
dc.identifier.wosWOS:000320002000003
dc.language.isoeng
dc.publisherFaculdade de Medicina / USP
dc.relation.ispartofClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSleep Apneaen
dc.subjectNeuropsychological Testsen
dc.subjectOxidative Stressen
dc.subjectVitamin Een
dc.subjectSuperoxide Dismutaseen
dc.titleCognition and biomarkers of oxidative stress in obstructive sleep apneaen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1807-59322013000400449.pdf
Tamanho:
343.96 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Artigos