Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers

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dc.contributor.authorRuiz, Francieli S.
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorMartins, Raquel C. S.
dc.contributor.authorZager, Adriano
dc.contributor.authorLopes, Jose D.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:54Z
dc.date.available2016-01-24T14:17:54Z
dc.date.issued2012-02-01
dc.description.abstractWe investigated the impact of two nights of total sleep deprivation (SD) or four nights of rapid eye movement (REM) SD on immunological parameters in healthy men. Thirty-two volunteers were randomly assigned to three protocols (control, total SD or REM SD). Both SD protocols were followed by three nights of sleep recovery. the control and REM SD groups had regular nights of sleep monitored by polysomnography. Circulating white blood cells (WBCs), T-(CD4/ CD8) and B-lymphocytes, Ig classes, complement and cytokine levels were assessed daily. Two nights of total SD increased the numbers of leukocytes and neutrophils compared with baseline levels, and these levels returned to baseline after 24 h of sleep recovery. the CD4(+) T-cells increased during the total SD period (one and two nights) and IgA levels decreased during the entire period of REM SD. These levels did not return to baseline after three nights of sleep recovery. Levels of monocytes, eosinophils, basophils and cytokines (IL-1 beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha and IFN-gamma) remained unchanged by both protocols of SD. Our findings suggest that both protocols affected the human immune profile, although in different parameters, and that CD4(+) T-cells and IgA levels were not re-established after sleep recovery.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 98/14303-3
dc.description.sponsorshipIDFAPESP: 07/55445-6
dc.description.sponsorshipIDFAPESP: 06/1676
dc.description.sponsorshipIDFAPESP: 06/58275-1
dc.format.extent44-54
dc.identifierhttp://dx.doi.org/10.1177/1753425910385962
dc.identifier.citationInnate Immunity. London: Sage Publications Ltd, v. 18, n. 1, p. 44-54, 2012.
dc.identifier.doi10.1177/1753425910385962
dc.identifier.issn1753-4259
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34614
dc.identifier.wosWOS:000299162600005
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofInnate Immunity
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectBlood cellsen
dc.subjectHumanen
dc.subjectimmune systemen
dc.subjectREM sleep deprivationen
dc.subjecttotal sleep deprivationen
dc.titleImmune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteersen
dc.typeinfo:eu-repo/semantics/article
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